CAS 1219804-03-1|4-Hydroxypropranolol D7 hydrochloride
Introduction：Basic information about CAS 1219804-03-1|4-Hydroxypropranolol D7 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroxypropranolol D7 hydrochloride | ||
|---|---|---|---|
| CAS Number | 1219804-03-1 | Molecular Weight | 282.386 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 487.5±35.0 °C at 760 mmHg |
| Molecular Formula | C16H15D7ClNO3 | Melting Point | / |
| MSDS | / | Flash Point | 248.6±25.9 °C |
Names
| Name | 4-[3-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-2-hydroxypropoxy]naphthalen-1-ol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
4-Hydroxypropranolol D7 hydrochloride BiologicalActivity
| Description | 4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
| Target | pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2] |
| References | [1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35. [2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61. [3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 487.5±35.0 °C at 760 mmHg |
| Molecular Formula | C16H15D7ClNO3 |
| Molecular Weight | 282.386 |
| Flash Point | 248.6±25.9 °C |
| Exact Mass | 282.196075 |
| PSA | 61.72000 |
| LogP | 2.27 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.602 |
| InChIKey | ROUJENUXWIFONU-BGKGEVRXSA-N |
| SMILES | CC(C)NCC(O)COc1ccc(O)c2ccccc12.Cl |
Synonyms
| 1-Naphthalenol, 4-[2-hydroxy-3-[[1-(methyl-d)ethyl-1,2,2,2-d]amino]propoxy]- |
| 4-{2-Hydroxy-3-[(H)-2-propanylamino]propoxy}-1-naphthol |
| [2H7]-4-Hydroxypropranolol hydrochloride |
