Introduction：Basic information about CAS 1132709-14-8|(1S,2S)-Bortezomib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (1S,2S)-Bortezomib |
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| CAS Number | 1132709-14-8 | Molecular Weight | 384.237 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C19H25BN4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | [(1S)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid |
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| Synonym | More Synonyms |
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(1S,2S)-Bortezomib BiologicalActivity
| Description | (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Proteasome |
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| Target | Ki: 0.6 nM (20S proteasome)[1] |
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| References | [1]. Kamalzadeh Z, et al. Determination of Bortezomib in API Samples Using HPLC: Assessment of Enantiomeric and Diastereomeric Impurities. J Chromatogr Sci. 2017 Aug 1;55(7):697-705. [2]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [3]. Shahshahan MA, et al. Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects. Am J Cancer Res. 2011;1(7):913-24. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C19H25BN4O4 |
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| Molecular Weight | 384.237 |
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| Exact Mass | 384.196899 |
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| PSA | 131.42000 |
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| LogP | 2.45 |
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| Index of Refraction | 1.564 |
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| InChIKey | GXJABQQUPOEUTA-DOTOQJQBSA-N |
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| SMILES | CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Boronic acid, B-[(1S)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]- |
| [(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid |
| N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide |
| N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide |
| HMS2089J16 |
| (1S,2S)-Bortezomib |
| ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid |
