Introduction：Basic information about CAS 67469-75-4|GBR 12783 dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GBR 12783 dihydrochloride |
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| CAS Number | 67469-75-4 | Molecular Weight | 485.48800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C28H34Cl2N2O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piper azine dihydrochloride |
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| Synonym | More Synonyms |
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GBR 12783 dihydrochloride BiologicalActivity
| Description | GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| In Vivo | GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; for 100 minutes Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo. |
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| References | [1]. Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. [2]. Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209. |
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Chemical & Physical Properties
| Molecular Formula | C28H34Cl2N2O |
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| Molecular Weight | 485.48800 |
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| Exact Mass | 484.20500 |
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| PSA | 15.71000 |
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| LogP | 6.60340 |
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| InChIKey | HJDXBLLTRMCYNC-JFXLULTRSA-N |
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| SMILES | C(=Cc1ccccc1)CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1.Cl.Cl |
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Safety Information
Synonyms
| 2,9,10(1H)-Anthracenetrione,6-ethyl-4,5-dihydroxy-1,1,3,7-tetramethyl |
| Kenpaullone |
| garvatin B quinone |
