Introduction：Basic information about CAS 111753-73-2|Satigrel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Satigrel |
|---|
| CAS Number | 111753-73-2 | Molecular Weight | 337.36900 |
|---|
| Density | 1.195g/cm3 | Boiling Point | 581.6ºC at 760mmHg |
|---|
| Molecular Formula | C20H19NO4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 305.6ºC |
|---|
Names
| Name | 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid |
|---|
| Synonym | More Synonyms |
|---|
Satigrel BiologicalActivity
| Description | Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively)[1]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Prostaglandin Receptor |
|---|
| References | [1]. N Nagakura, et al. Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33. |
|---|
Chemical & Physical Properties
| Density | 1.195g/cm3 |
|---|
| Boiling Point | 581.6ºC at 760mmHg |
|---|
| Molecular Formula | C20H19NO4 |
|---|
| Molecular Weight | 337.36900 |
|---|
| Flash Point | 305.6ºC |
|---|
| Exact Mass | 337.13100 |
|---|
| PSA | 79.55000 |
|---|
| LogP | 3.89408 |
|---|
| Vapour Pressure | 2.27E-14mmHg at 25°C |
|---|
| Index of Refraction | 1.578 |
|---|
| InChIKey | GRVCTHTXJDYIHB-UHFFFAOYSA-N |
|---|
| SMILES | COc1ccc(C(=C(C#N)CCC(=O)O)c2ccc(OC)cc2)cc1 |
|---|
Synonyms
| E5510 |
| 5,5-Bis(4-methoxyphenyl)-4-cyano-4-pentenoic acid |
| Satigrel |
| 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid |
| 4-Pentenoic acid,4-cyano-5,5-bis(4-methoxyphenyl) |
| 4-Pentenoic acid,5,5-bis(4-methoxyphenyl)-4-cyano |
