Introduction：Basic information about CAS 205881-86-3|SL-651,498, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SL-651,498 |
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| CAS Number | 205881-86-3 | Molecular Weight | 389.42200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H20FN3O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6-Fluoro-9-methyl-2-phenyl-4-(1-pyrrolidinylcarbonyl)-2,9-dihydro -1H-β-carbolin-1-one |
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SL-651,498 BiologicalActivity
| Description | SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| References | [1]. G Griebel, et al. SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors. J Pharmacol Exp Ther. 2001 Aug;298(2):753-68. |
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Chemical & Physical Properties
| Molecular Formula | C23H20FN3O2 |
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| Molecular Weight | 389.42200 |
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| Exact Mass | 389.15400 |
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| PSA | 47.24000 |
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| LogP | 3.79540 |
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| InChIKey | QQWHWWDIFGNCLV-UHFFFAOYSA-N |
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| SMILES | Cn1c2ccc(F)cc2c2c(C(=O)N3CCCC3)cn(-c3ccccc3)c(=O)c21 |
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