Introduction：Basic information about CAS 115308-98-0|Tallimustine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tallimustine |
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| CAS Number | 115308-98-0 | Molecular Weight | 697.61500 |
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| Density | 1.41g/cm3 | Boiling Point | / |
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| Molecular Formula | C32H38Cl2N10O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1-methylpyrrole-2-carboxamide |
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| Synonym | More Synonyms |
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Tallimustine BiologicalActivity
| Description | Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent[1][2][4]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA[1]. Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC50 of 3.5 nM[1]. Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells[2]. Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells[2]. Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase[3]. Cell Viability Assay[2] Cell Line: K562 cells Concentration: 25 and 100 nM Incubation Time: 4 days Result: Inhibited cell proliferation. |
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| In Vivo | Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice[4]. Animal Model: L1210 tumor bearing mice[2]. Dosage: 3 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Prolonged the survival of mice. |
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Chemical & Physical Properties
| Density | 1.41g/cm3 |
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| Molecular Formula | C32H38Cl2N10O4 |
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| Molecular Weight | 697.61500 |
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| Exact Mass | 696.24500 |
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| PSA | 184.30000 |
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| LogP | 5.20880 |
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| Index of Refraction | 1.668 |
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| InChIKey | ARKYUICTMUZVEW-UHFFFAOYSA-N |
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| SMILES | Cn1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4ccc(N(CCCl)CCCl)cc4)cn3C)cn2C)cc1C(=O)NCCC(=N)N |
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Synonyms
| 1H-Pyrrole-2-carboxamide,N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl |
| Tallimustine |
| Tallimustine [INN] |
