CAS 304-47-2|Kynuramine Dihydrobromide
| Common Name | Kynuramine Dihydrobromide | ||
|---|---|---|---|
| CAS Number | 304-47-2 | Molecular Weight | 326.02800 |
| Density | / | Boiling Point | 367.3ºC at 760mmHg |
| Molecular Formula | C9H14Br2N2O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 175.9ºC |
Names
| Name | Kynuramine dihydrobromide |
|---|---|
| Synonym | More Synonyms |
Kynuramine Dihydrobromide BiologicalActivity
| Description | Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Metabolic Disease |
| In Vitro | Kynuramine (dihydrobromide) 在体外抑制突触前和突触后 α-肾上腺素受体[2]。 Kynuramine 已被证明是狗脑动脉血清素受体的部分激动剂[2]。 Kynuramine (20 μg/mL) 经常导致回肠轻微收缩，但未能改变胆碱能刺激的抽搐反应[2]。 |
| In Vivo | Kynuramine (dihydrobromide) (0.064、0.32、1.6 或 8 μg；脑室内；单剂量) 促进雌激素激发的去卵巢大鼠前凸行为[3]。 Kynuramine (1.25、2.5 和 5.0 mg/kg；静脉注射；单剂量) 可增加大鼠的心率和血压[4]。 Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular injection; single does. Result: Produced facilitation of lordosis behavior. Animal Model: Male rats (about 200g)[4]. Dosage: 1.25-5.0 mg/kg. Administration: Intravenous injection; single does. Result: Promoted heart rate and blood pressure. |
| References | [1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6. |
Chemical & Physical Properties
| Boiling Point | 367.3ºC at 760mmHg |
|---|---|
| Molecular Formula | C9H14Br2N2O |
| Molecular Weight | 326.02800 |
| Flash Point | 175.9ºC |
| Exact Mass | 323.94700 |
| PSA | 69.11000 |
| LogP | 3.99800 |
| InChIKey | KNLPLQJBAIXOQE-UHFFFAOYSA-N |
| SMILES | Br.Br.NCCC(=O)c1ccccc1N |
| Storage condition | 20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Synonyms
| 3-(2-Aminophenyl)-3-oxopropanamine |
| 3-amino-1-(2-aminophenyl)propan-1-one,hydrobromide |
