CAS 1262776-24-8|Clothianidine-d3
| Common Name | Clothianidine-d3 | ||
|---|---|---|---|
| CAS Number | 1262776-24-8 | Molecular Weight | 252.697 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 435.2±55.0 °C at 760 mmHg |
| Molecular Formula | C6H5ClD3N5O2S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 217.0±31.5 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | 2-[(2-chloro-1,3-thiazol-5-yl)methyl]-1-nitro-3-(trideuteriomethyl)guanidine |
|---|---|
| Synonym | More Synonyms |
Clothianidine-d3 BiologicalActivity
| Description | Clothianidin-d3 is the deuterium labeled Clothianidin. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 435.2±55.0 °C at 760 mmHg |
| Molecular Formula | C6H5ClD3N5O2S |
| Molecular Weight | 252.697 |
| Flash Point | 217.0±31.5 °C |
| Exact Mass | 252.027557 |
| PSA | 123.37000 |
| LogP | -0.15 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.709 |
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H410 |
| Precautionary Statements | P273-P501 |
| RIDADR | UN 3077 9 / PGIII |
Articles4
More Articles| Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014) A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ... | |
| Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. PLoS ONE 11 , e0146335, (2016) Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha... | |
| Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario. Environ. Toxicol. Chem. 35 , 295-302, (2016) Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration... |
Synonyms
| 1-[(2-chlorothiazol-5-yl)methyl]-2-nitro-3-(trideuteriomethyl)guanidine |
| 1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-(H)methyl-3-nitroguanidine |
| Clothianidin-d3 |
| Clothianidine-d3 |
| (E)-1-(2-Chloro-5-thiazolylmethyl)-3-(methyl-d3)-2-nitroguanidine |
| Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N'-methyl-d-N''-nitro- |
