CAS 154540-49-5|Fluoroclebopride

Introduction：Basic information about CAS 154540-49-5|Fluoroclebopride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fluoroclebopride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Fluoroclebopride
CAS Number	154540-49-5	Molecular Weight	391.867
Density	1.3±0.1 g/cm3	Boiling Point	518.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₃ClFN₃O₂	Melting Point	/
MSDS	/	Flash Point	267.2±30.1 °C

Names

Name	Fluoroclebopride
Synonym	More Synonyms

Fluoroclebopride BiologicalActivity

Description	Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
References	[1]. Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82. [2]. Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29:10.1007/s00213-013-3274-7.

Description

Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease

References

[1]. Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82.

[2]. Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29:10.1007/s00213-013-3274-7.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	518.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₃ClFN₃O₂
Molecular Weight	391.867
Flash Point	267.2±30.1 °C
Exact Mass	391.146271
PSA	71.08000
LogP	2.69
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.618
InChIKey	HKDIGEWWDHALIS-UHFFFAOYSA-N
SMILES	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccc(F)cc2)CC1

Synonyms

4-AMINO-5-CHLORO-N-(1-((4-FLUOROPHENYL)METHYL)-PIPERIDIN-4-YL)-2-METHOX YBENZAMIDE

4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methoxybenzamide

4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]-2-methoxybenzamide

4-amino-5-chloro-N-[1-(4-fluorobenzyl)piperidin-4-yl]-2-methoxybenzamide

Benzamide, 4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-

4-Amino-5-chloro-N-[1-(4-fluorobenzyl)-4-piperidinyl]-2-methoxybenzamide

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