Introduction：Basic information about CAS 120-05-8|sulfurein, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | sulfurein |
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| CAS Number | 120-05-8 | Molecular Weight | 270.237 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 585.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C15H10O5 | Melting Point | 295ºC |
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| MSDS | / | Flash Point | 228.8±23.6 °C |
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Names
| Name | sulfuretin |
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| Synonym | More Synonyms |
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sulfurein BiologicalActivity
| Description | Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| In Vitro | Sulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation. |
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| In Vivo | Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1]. Animal Model: Pathogen-free male BALB/c mice (7-8 weeks old)[1] Dosage: 40 μg/kg Administration: A single intraperitoneal injection was administered 2 h after the last OVA challenge Result: Suppressed OVA-induced chemotaxis and airway inflammation. |
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| References | [1]. Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. [2]. Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 585.0±50.0 °C at 760 mmHg |
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| Melting Point | 295ºC |
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| Molecular Formula | C15H10O5 |
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| Molecular Weight | 270.237 |
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| Flash Point | 228.8±23.6 °C |
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| Exact Mass | 270.052826 |
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| PSA | 86.99000 |
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| LogP | 1.98 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.793 |
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| InChIKey | RGNXWPVNPFAADO-NSIKDUERSA-N |
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| SMILES | O=C1C(=Cc2ccc(O)c(O)c2)Oc2cc(O)ccc21 |
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Safety Information
Synonyms
| Sulfuretin |
| (Z)-2-((3,4-Dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one |
| 3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-, (2Z)- |
| (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one |
| 2-(3,4-Dihydroxybenzylidene)-6-hydroxy-3(2H)-benzofuranone |
| sulfurein |
| 7,3',4'-trihydroxyaurone |
| Sulphuretin |
| MFCD00017304 |
| 3',4',6-Trihydroxybenzalcoumaranone |
| 3',4',6-trihydroxyaurone |
| (2Z)-2-(3,4-Dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one |
| 2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone |
