Introduction：Basic information about CAS 7380-39-4|5-Geranoxy-7-methoxycoumarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Geranoxy-7-methoxycoumarin |
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| CAS Number | 7380-39-4 | Molecular Weight | 328.40 |
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| Density | 1.092g/cm3 | Boiling Point | 487.1ºC at 760 mmHg |
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| Molecular Formula | C20H24O4 | Melting Point | 86-88ºC |
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| MSDS | / | Flash Point | 213.2ºC |
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Names
| Name | 5-[(2E)-3,7-dimethylocta-2,6-dienoxy]-7-methoxychromen-2-one |
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| Synonym | More Synonyms |
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5-Geranoxy-7-methoxycoumarin BiologicalActivity
| Description | 5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | 5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1]. Cell Proliferation Assay[1] Cell Line: SW480 Concentration: 0-20 μM Incubation Time: 24, 48 and 72 hours Result: Inhibited cell growth by 67% at 72 hours. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited cell cycle progression in vitro. |
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| References | [1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26. [2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine |
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Chemical & Physical Properties
| Density | 1.092g/cm3 |
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| Boiling Point | 487.1ºC at 760 mmHg |
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| Melting Point | 86-88ºC |
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| Molecular Formula | C20H24O4 |
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| Molecular Weight | 328.40 |
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| Flash Point | 213.2ºC |
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| Exact Mass | 328.16700 |
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| PSA | 48.67000 |
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| LogP | 4.87310 |
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| Index of Refraction | 1.542 |
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| InChIKey | WXUOSNJWDJOHGW-XNTDXEJSSA-N |
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| SMILES | COc1cc(OCC=C(C)CCC=C(C)C)c2ccc(=O)oc2c1 |
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| Storage condition | -20°C |
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Synonyms
| 5-Geranoxy-7-methoxy-cumarin |
| 5-geranyloxy-7-methoxycoumarin |
| 5-Geranoxy-7-methoxycoumarin |
| 7-Methoxy-5-geranoxycoumarin |
