CAS 42155-08-8|Disodium 2'-deoxy-5'-O-phosphonatouridine
| Common Name | Disodium 2'-deoxy-5'-O-phosphonatouridine | ||
|---|---|---|---|
| CAS Number | 42155-08-8 | Molecular Weight | 352.146 |
| Density | 1.742 g/cm3 | Boiling Point | / |
| Molecular Formula | C9H11N2Na2O8P | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2′-Deoxyuridine 5′-mono-phos-phate disodium salt |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| References | [1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. |
Chemical & Physical Properties
| Density | 1.742 g/cm3 |
|---|---|
| Molecular Formula | C9H11N2Na2O8P |
| Molecular Weight | 352.146 |
| Exact Mass | 352.004852 |
| PSA | 166.55000 |
| InChIKey | FXVXMLXAXVVONE-CDNBRZBRSA-L |
| SMILES | O=c1ccn(C2CC(O)C(COP(=O)([O-])[O-])O2)c(=O)[nH]1.[Na+].[Na+] |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R22 |
| Safety Phrases | 26-36-37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 2937-2944, (2009) To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectro... | |
| Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX. Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8924-9, (2013) In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride dono... | |
| Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J. Neurosci. 28 , 7219-7230, (2008) Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie... |
Synonyms
| 5'-Uridylic acid, 2'-deoxy-, sodium salt (1:2) |
| 2'-Deoxyuridine 5'-monophosphate disodium salt |
| EINECS 255-687-1 |
| Disodium 2'-deoxy-5'-O-phosphonatouridine |
| MFCD00065282 |
| 2'-Deoxyuridine 5'-mono-phos-phate disodium salt |
