CAS 83-73-8|Diiodohydroxyquinoline

Introduction：Basic information about CAS 83-73-8|Diiodohydroxyquinoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Diiodohydroxyquinoline BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles26
8. Synonyms

Common Name	Diiodohydroxyquinoline
CAS Number	83-73-8	Molecular Weight	396.951
Density	2.5±0.1 g/cm3	Boiling Point	401.8±45.0 °C at 760 mmHg
Molecular Formula	C₉H₅I₂NO	Melting Point	>200 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	196.8±28.7 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	5,7-Diiodo-8-hydroxyquinoline
Synonym	More Synonyms

Diiodohydroxyquinoline BiologicalActivity

Description	Diiodohydroxyquinoline is a topical therapeutic agent, with satisfactory antibacterial properties.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

Chemical & Physical Properties

Density	2.5±0.1 g/cm3
Boiling Point	401.8±45.0 °C at 760 mmHg
Melting Point	>200 °C (dec.)(lit.)
Molecular Formula	C₉H₅I₂NO
Molecular Weight	396.951
Flash Point	196.8±28.7 °C
Exact Mass	396.846039
PSA	33.12000
LogP	4.11
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.828
InChIKey	UXZFQZANDVDGMM-UHFFFAOYSA-N
SMILES	Oc1c(I)cc(I)c2cccnc12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5775000

CHEMICAL NAME :: 8-Quinolinol, 5,7-diiodo-

CAS REGISTRY NUMBER :: 83-73-8

BEILSTEIN REFERENCE NO. :: 0153639

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C9-H5-I2-N-O

MOLECULAR WEIGHT :: 396.95

WISWESSER LINE NOTATION :: T66 BNJ GI II JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 819 mg/kg/13D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - oxidant related (GPD deficient) anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 120 gm/kg/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >40 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Liver - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,219,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80403 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S26-S36/37/39
RIDADR	3249
WGK Germany	3
RTECS	VC5775000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933499090

Customs

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles26

Effects of oral administration of zinc and diiodohydroxyquinolein on plasma zinc levels of uremic patients.

Nephron 69(2) , 147-50, (1995)

Patients with chronic renal failure often have low plasma zinc (Zn) levels. Some factors that may account for abnormal Zn metabolism in these patients are low dietary Zn intake, a specific Zn transpor...

Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture.

Pak. J. Pharm. Sci. 26(5) , 865-71, (2013)

Two chromatographic methods were developed for analysis ofdiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, diiodohydroxyquinoline and metronidazole were separated on TLC sil...

LC of pharmaceutically important halogenated 8-hydroxyquinolines after precolumn derivatization with Pd (II).

J. Pharm. Biomed. Anal. 27(5) , 813-20, (2002)

An accurate, sensitive, and selective reversed phase high performance liquid chromatographic (HPLC) method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; clioquinol ...

Synonyms

Disoquin

Dyodin

Rafamebin

ZOAQUIN

Diiodo-oxyquinoline

8-Hydroxy-5,7-diiodoquinoline

EINECS 201-497-9

Searlequin

5,7-diiodoquinolin-8-ol

Yodoxin

5,7-Diiodooxine

Diiodohydroxyquinolin

MFCD00006789

8-Quinolinol, 5,7-diiodo-

Dinoleine

Embequin

IODOQUINOL

Diiodohydroxyquinoline

Stanquinate

Enterosept

Iodoquinol (USP)

Diodoquin

Ioquin

Direxiode

5,7-Diiodo-8-quinolinol

Diodoxylin

Diiodoquinol

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