Introduction：Basic information about CAS 875770-34-6|Biotin-PEG3-azide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin-PEG3-azide |
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| CAS Number | 875770-34-6 | Molecular Weight | 444.549 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H32N6O5S | Melting Point | 110 °C |
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| MSDS | USA | Flash Point | / |
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Names
| Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]pentanamide |
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| Synonym | More Synonyms |
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Biotin-PEG3-azide BiologicalActivity
| Description | Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | Biotin-C2-PEG3-azide is a biotin with the azide tag, it can be conjugated to antiviral inhibitors, for example, RYL-634, which shows excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
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| References | [1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.J Med Chem. 2019 Apr 25;62(8):4056-4073. |
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Chemical & Physical Properties
| Melting Point | 110 °C |
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| Molecular Formula | C18H32N6O5S |
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| Molecular Weight | 444.549 |
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| Exact Mass | 444.215485 |
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| PSA | 179.95000 |
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| LogP | -0.93 |
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| InChIKey | ZWFOOMQCYIGZBE-ZOBUZTSGSA-N |
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| SMILES | [N-]=[N+]=NCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- |
| Biotin-PEG3-Azide |
| N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
