CAS 128-09-6|N-chlorosuccinimide
| Common Name | N-chlorosuccinimide | ||
|---|---|---|---|
| CAS Number | 128-09-6 | Molecular Weight | 133.533 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 200.5±23.0 °C at 760 mmHg |
| Molecular Formula | C4H4ClNO2 | Melting Point | 148-150 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 75.1±22.6 °C |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | N-chlorosuccinimide |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 200.5±23.0 °C at 760 mmHg |
| Melting Point | 148-150 °C(lit.) |
| Molecular Formula | C4H4ClNO2 |
| Molecular Weight | 133.533 |
| Flash Point | 75.1±22.6 °C |
| Exact Mass | 132.993057 |
| PSA | 37.38000 |
| LogP | -0.87 |
| Vapour Pressure | 0.3±0.4 mmHg at 25°C |
| Index of Refraction | 1.532 |
| InChIKey | JRNVZBWKYDBUCA-UHFFFAOYSA-N |
| SMILES | O=C1CCC(=O)N1Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 gm/kg/40D-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5800 mg/kg/5W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells
- REFERENCE :
- PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 840 mg/kg/70W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 53,695,1974
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C:Corrosive |
| Risk Phrases | R22;R34 |
| Safety Phrases | S26-S36/37/39-S45-S37/39 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | UY1013500 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2933990090 |
Customs
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles115
More Articles| Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharm. Res. 32(5) , 1546-56, (2015) To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides.Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide ... | |
| Induction of Local Secretory IgA and Multifunctional CD4⁺ T-helper Cells Following Intranasal Immunization with a H5N1 Whole Inactivated Influenza Virus Vaccine in BALB/c Mice. Scand. J. Immunol. 81 , 305-17, (2015) Avian influenza subunit vaccines have been shown to be poorly immunogenic, leading to the re-evaluation of the immunogenic and dose-sparing potential of whole virus vaccines. In this study, we investi... | |
| Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U. S. A. 112 , E3199-206, (2015) Most secretory cargo proteins in eukaryotes are synthesized in the endoplasmic reticulum and actively exported in membrane-bound vesicles that are formed by the cytosolic coat protein complex II (COPI... |
Synonyms
| succinimide, N-chloro- |
| Chlorosuccinimide |
| EINECS 204-878-8 |
| N-chlorobutanimide |
| 1-Chloro-2,5-pyrrolidinedione |
| 2,5-Pyrrolidinedione, 1-chloro- |
| Succinimide, N-chloro- (8CI) |
| 1-chloropyrrolidine-2,5-dione |
| N-Chlorosuccinimide |
| MFCD00005511 |
