CAS 871307-18-5|TC-S 7006

Introduction：Basic information about CAS 871307-18-5|TC-S 7006, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. TC-S 7006 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	TC-S 7006
CAS Number	871307-18-5	Molecular Weight	404.82700
Density	/	Boiling Point	/
Molecular Formula	C₂₁H₁₄ClFN₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
Synonym	More Synonyms

TC-S 7006 BiologicalActivity

Description	Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].
Related Catalog	Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>MAPK/ERK Pathway >>MAP3K
Target	MAP3K8
In Vitro	Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1].
References	[1]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

Chemical & Physical Properties

Molecular Formula	C₂₁H₁₄ClFN₆
Molecular Weight	404.82700
Exact Mass	404.09500
PSA	86.52000
LogP	5.19068
InChIKey	NMEUKWOOQOHUNA-UHFFFAOYSA-N
SMILES	N#Cc1cnc2cnc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1

Safety Information

HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile

Tpl2 Kinase Inhibitor

4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE

4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

Recommended......