Introduction：Basic information about CAS 1448346-63-1|AG-120, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AG-120 |
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| CAS Number | 1448346-63-1 | Molecular Weight | 582.96 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 854.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C28H22ClF3N6O3 | Melting Point | / |
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| MSDS | / | Flash Point | 470.4±34.3 °C |
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Names
| Name | (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
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| Synonym | More Synonyms |
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AG-120 BiologicalActivity
| Description | IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Isocitrate Dehydrogenase (IDH) |
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| References | [1]. Rene M, et al. Therapeutically active compounds and their methods of use. Patent. WO2013107291. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 854.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C28H22ClF3N6O3 |
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| Molecular Weight | 582.96 |
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| Flash Point | 470.4±34.3 °C |
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| Exact Mass | 582.139404 |
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| PSA | 119.29000 |
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| LogP | 0.38 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.651 |
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| InChIKey | WIJZXSAJMHAVGX-XADRRFQNSA-N |
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| SMILES | N#Cc1ccnc(N2C(=O)CCC2C(=O)N(c2cncc(F)c2)C(C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1 |
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Synonyms
| 2-Pyrrolidinecarboxamide, N-[1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-, (2S)- |
| N-{1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide |
| (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| AG-120 |
