Introduction：Basic information about CAS 21416-53-5|Picrotin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Picrotin |
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| CAS Number | 21416-53-5 | Molecular Weight | 310.29900 |
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| Density | 1.59g/cm3 | Boiling Point | 595.8ºC at 760 mmHg |
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| Molecular Formula | C15H18O7 | Melting Point | 256-258ºC |
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| MSDS | ChineseUSA | Flash Point | 228.9ºC |
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Names
| Name | picrotin |
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| Synonym | More Synonyms |
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Picrotin BiologicalActivity
| Description | Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | α2 GlyR, α1 GlyR, α3 GlyR[1][2] |
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| References | [1]. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20. [2]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. |
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Chemical & Physical Properties
| Density | 1.59g/cm3 |
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| Boiling Point | 595.8ºC at 760 mmHg |
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| Melting Point | 256-258ºC |
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| Molecular Formula | C15H18O7 |
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| Molecular Weight | 310.29900 |
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| Flash Point | 228.9ºC |
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| Exact Mass | 310.10500 |
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| PSA | 105.59000 |
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| Vapour Pressure | 1.12E-16mmHg at 25°C |
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| Index of Refraction | 1.637 |
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| InChIKey | RYEFFICCPKWYML-QCGISDTRSA-N |
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| SMILES | CC(C)(O)C1C2OC(=O)C1C1(O)CC3OC34C(=O)OC2C14C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TJ8800000
- CHEMICAL NAME :
- Picrotin
- CAS REGISTRY NUMBER :
- 21416-53-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H18-O7
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,729,1968
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | TJ8800000 |
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Synonyms
| (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione |
| picrotoxin component 2 |
| (-)-Picrotin |
