CAS 30462-35-2|Theaflavin 3,3'-di-O-gallate
Introduction：Basic information about CAS 30462-35-2|Theaflavin 3,3'-di-O-gallate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Theaflavin 3,3'-di-O-gallate | ||
|---|---|---|---|
| CAS Number | 30462-35-2 | Molecular Weight | 868.702 |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 1324.7±65.0 °C at 760 mmHg |
| Molecular Formula | C43H32O20 | Melting Point | 226-230℃ |
| MSDS | USA | Flash Point | 402.9±27.8 °C |
Names
| Name | [(2R,3R)-2-[1-[(2R,3R)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,5-trihydroxy-6-oxobenzo[7]annulen-8-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
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| Synonym | More Synonyms |
Theaflavin 3,3'-di-O-gallate BiologicalActivity
| Description | Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>MEKSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | Akt NF-κB MEK1 MEK2 ERK1 ERK2 |
| References | [1]. Ding Y, et al. Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line. Food Nutr Res. 2017 Nov 15;61(1):1400340. |
Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 1324.7±65.0 °C at 760 mmHg |
| Melting Point | 226-230℃ |
| Molecular Formula | C43H32O20 |
| Molecular Weight | 868.702 |
| Flash Point | 402.9±27.8 °C |
| Exact Mass | 868.148682 |
| PSA | 351.12000 |
| LogP | 3.88 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.908 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 29329990 |
Articles1
More Articles| Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. Prostate 75(5) , 550-9, (2015) Preclinical and epidemiologic studies suggest chemopreventive effects of green tea (GT) and black tea (BT) in prostate cancer. In the current study we determined the effect of GT and BT consumption on... |
Synonyms
| 8-Gingerol |
| (3,4,5-Trihydroxy-6-oxo-6H-benzo[7]annulene-1,8-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate) |
| theaflavin 3,3'-O-digallate |
| Theaflavin-3,3'-digallate |
| theaflavin-3,3'-di-O-gallate |
| theaflavin 3,3'-gallate |
| Benzoic acid, 3,4,5-trihydroxy-, (3,4,5-trihydroxy-6-oxo-6H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl] ester |
| Theaflavin digallate |
| TF-3 |
| Theaflavin 3,3'-digallate |
