CAS 70831-56-0|Chicoric acid

Introduction：Basic information about CAS 70831-56-0|Chicoric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chicoric acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles26
6. Synonyms

Common Name	Chicoric acid
CAS Number	70831-56-0	Molecular Weight	474.371
Density	1.6±0.1 g/cm3	Boiling Point	785.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₈O₁₂	Melting Point	206 °C
MSDS	USA	Flash Point	272.9±26.4 °C

Names

Name	Cichoric acid
Synonym	More Synonyms

Chicoric acid BiologicalActivity

Description	L-Chicoric acid is an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase in vitro and of HIV-1 replication in tissue culture. IC50 value:Target:In vitro: Using quantitative real-time polymerase chain reaction (PCR), l-CA inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM [1]. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350) [2]. L-chicoric acid inhibits integrase and that the drug is likely to interact at residues near the catalytic triad in the integrase active site [3].In vivo:
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>InfectionNatural Products >>Phenylpropanoids
References	[1]. Ryan A Reinke, et al. l-Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology Volume 326, Issue 2, 1 September 2004, Pages 203–219 [2]. W Edward Robinson Jr., et al. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350). Antiviral Research Volume 39, Issue 2, Augu [3]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. Journal of Virology, 1998, 72(10): 8420-8424

Description

L-Chicoric acid is an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase in vitro and of HIV-1 replication in tissue culture. IC50 value:Target:In vitro: Using quantitative real-time polymerase chain reaction (PCR), l-CA inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM [1]. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350) [2]. L-chicoric acid inhibits integrase and that the drug is likely to interact at residues near the catalytic triad in the integrase active site [3].In vivo:

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>InfectionNatural Products >>Phenylpropanoids

References

[1]. Ryan A Reinke, et al. l-Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology Volume 326, Issue 2, 1 September 2004, Pages 203–219

[2]. W Edward Robinson Jr., et al. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350). Antiviral Research Volume 39, Issue 2, Augu

[3]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. Journal of Virology, 1998, 72(10): 8420-8424

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	785.0±60.0 °C at 760 mmHg
Melting Point	206 °C
Molecular Formula	C₂₂H₁₈O₁₂
Molecular Weight	474.371
Flash Point	272.9±26.4 °C
Exact Mass	474.079834
PSA	208.12000
LogP	3.81
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.726
InChIKey	YDDGKXBLOXEEMN-IABMMNSOSA-N
SMILES	O=C(C=Cc1ccc(O)c(O)c1)OC(C(=O)O)C(OC(=O)C=Cc1ccc(O)c(O)c1)C(=O)O
Storage condition	−20°C

Safety Information

Hazard Codes	Xn
Risk Phrases	22-42/43
Safety Phrases	22-36/37-45
RIDADR	NONH for all modes of transport

Articles26

[Simultaneous determination of five organic acids in Kudiezi injection by HPLC].

Zhongguo Zhong Yao Za Zhi 38(19) , 3287-90, (2013)

The aim was to develop a high performance liquid chromatography method for simultaneous determination of five organic acids in Kudiezi injection. The Diamonsil C18 column (4.6 mm x 200 mm, 5 microm) w...

Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts.

J. Pharm. Pharmacol. 65(2) , 271-9, (2013)

To use an online assay to identify key antioxidants in Sonchus oleraceus leaf extracts and to investigate the effect of leaf position and extraction conditions on antioxidant concentration and activit...

Echinacea alkylamides modulate induced immune responses in T-cells.

Fitoterapia 79(1) , 53-8, (2008)

The effects of Echinacea and several of its phytochemical components on NFkappaB expression by Jurkat cells (a human T-cell line) were investigated in vitro. In the absence of stimulation, Echinacea a...

Synonyms

Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-, (2S,3S)-

CICHORINIC ACID

(2S,3S)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid

D-Chicoric acid

(2S,3S)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}succinic acid

Cichoric acid

chicoric acid

CHICHORIC ACID

Echinacea Extract

L-CHICORIC ACID

MFCD00189418

(2r,3r)-2,3-bis[[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid

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