CAS 126-14-7|Sucrose octaacetate
Introduction：Basic information about CAS 126-14-7|Sucrose octaacetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sucrose octaacetate | ||
|---|---|---|---|
| CAS Number | 126-14-7 | Molecular Weight | 678.590 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 668.3±55.0 °C at 760 mmHg |
| Molecular Formula | C28H38O19 | Melting Point | 82-85 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 275.0±31.5 °C |
Names
| Name | Sucrose octaacetate |
|---|---|
| Synonym | More Synonyms |
Sucrose octaacetate BiologicalActivity
| Description | Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Sucrose octaacetate is nontoxic and has a number of uses based on its bitter taste. For example, sugar is rendered too bitter is eat at a concentration of 0.06% (w/w) Sucrose octaacetate. Sucrose octaacetate can form 255 different possible isomers and degradation products, all of which have a very low molar absorptivity[1]. Polyaniline (PANI) nanofibers and nanorods are obtained using 2 and 3 g Sucrose octaacetate, respectively. The nanostructures containing irregular-shaped agglomerates, such as particulate particles and scaffolds are observed with increasing the concentrations of Sucrose octaacetate. The presence of Sucrose octaacetate during polymerization could only induce a change in morphology, but could not influence the molecular structure of the resulting PANI. Compared with those derived with 1, 3, and 4 g Sucrose octaacetate, the polymerized PANI from 2 g Sucrose octaacetate possesses higher thermal stability and electrical conductivity due to its higher crystallinity and highly ordered structure[3]. |
| In Vivo | No recombination has been found between Sucrose octaacetate-avoidance phenotype and PRP haplotype in any mouse population. Soa and Prp, therefore, are either very near each other or identical. To assess the latter possibility, two type-A, proline-rich protein genes (MP2 and M14), situated approximately 30 kb apart at the Prp locus, are separately transferred from a Sucrose octaacetate-taster inbred strain (SWR) to a Sucrose octaacetate-nontaster inbred strain (FVB). Five MP2-transgenic mice and seven M14-transgenic mice are insensitive to 1 mM Sucrose octaacetate in two-bottle tests, thus retaining the nontaster FVB phenotype. Expression of mRNAs for both type-A Prp genes alone or together do not enhance SOA taste sensitivity in nontaster mice[2]. |
| References | [1]. William CraigStagner, et al. Chapter Five - Sucrose octaacetate. Profiles of Drug Substances, Excipients and Related Methodology. Volume 44, 2019, Pages 267-291. [2]. Harder DB, et al. Sucrose octaacetate avoidance in nontaster mice is not enhanced by two type-A Prp transgenes from taster mice. Chem Senses. 2000 Feb;25(1):39-45. [3]. HuaQiu, et al. Synthesis of polyaniline nanostructures via soft template of sucrose octaacetate. Synthetic Metals.Volume 160, Issues 11–12, June 2010, Pages 1179-1183. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 668.3±55.0 °C at 760 mmHg |
| Melting Point | 82-85 °C(lit.) |
| Molecular Formula | C28H38O19 |
| Molecular Weight | 678.590 |
| Flash Point | 275.0±31.5 °C |
| Exact Mass | 678.200745 |
| PSA | 238.09000 |
| LogP | 3.19 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.509 |
| InChIKey | ZIJKGAXBCRWEOL-SAXBRCJISA-N |
| SMILES | CC(=O)OCC1OC(OC2(COC(C)=O)OC(COC(C)=O)C(OC(C)=O)C2OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O |
| Storage condition | 2-8°C |
| Water Solubility | SLIGHTLY SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,827,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,827,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,827,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2306 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 77 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2306 No. of Facilities: 104 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1862 (estimated) No. of Female Employees: 1511 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | WN6620000 |
| HS Code | 2940000000 |
Customs
| HS Code | 2940000000 |
|---|
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| Gustatory responsiveness to six bitter tastants in three species of nonhuman primates. J. Chem. Ecol. 35(5) , 560-71, (2009) Gustatory responsiveness of six adult squirrel monkeys, four spider monkeys, and five pigtail macaques to six bitter tastants was assessed in two-bottle preference tests of brief duration (2 min). Ani... | |
| B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion. Behav. Genet. 41(5) , 716-23, (2011) Based on crosses among inbred strains derived principally from M. m. domesticus, sucrose octaacetate (SOA) aversion in laboratory mice has been thought for many years to be controlled by a single gene... |
Synonyms
| D-SucroseOctoacetate |
| aacetate |
| sucrose octa-acetate |
| Soa |
| 1,3,4,6-Tetra-O-acetyl-β-D-fructofuranosyl 2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside |
| Octa-O-acetyl D-(+)-Saccharose |
| Sucrose Octaacetate |
| α-D-Glucopyranoside, 1,3,4,6-tetra-O-acetyl-β-D-fructofuranosyl, tetraacetate |
| SUCROSE OCTACETATE |
| Sucroseoctaacetate |
| Sucrose OCLaacetate |
| Octa-O-acetyl D-(+)-Sucrose |
| D-(+)-Sucroseoctaacetate |
| octa-O-acetyl-sucrose |
| EINECS 204-772-1 |
| OCTAACETYLSUCROSE |
| Sucrose octa actate |
| D-(+)-Saccharose Octaacetate |
| MFCD00006623 |
| D-(+)-Sucrose Octaacetate |
| 1,3,4,6-Tetra-O-acetyl-b-D-fructofuranosyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside |
