Introduction：Basic information about CAS 125697-93-0|Lavendustin C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lavendustin C |
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| CAS Number | 125697-93-0 | Molecular Weight | 275.257 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 597.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C14H13NO5 | Melting Point | 193-195ºC dec. |
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| MSDS | ChineseUSA | Flash Point | 315.2±30.1 °C |
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Names
| Name | lavendustin c |
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| Synonym | More Synonyms |
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Lavendustin C BiologicalActivity
| Description | Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Neuronal Signaling >>CaMKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Src |
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| Target | CaMK II:0.2 μM (IC50) EGFR:0.012 μM (IC50) |
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| In Vitro | Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1]. Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3]. |
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| References | [1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7. [2]. T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60. [3]. H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55(1):112-9. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 597.5±50.0 °C at 760 mmHg |
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| Melting Point | 193-195ºC dec. |
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| Molecular Formula | C14H13NO5 |
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| Molecular Weight | 275.257 |
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| Flash Point | 315.2±30.1 °C |
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| Exact Mass | 275.079376 |
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| PSA | 110.02000 |
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| LogP | 1.74 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.759 |
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| InChIKey | LULATDWLDJOKCX-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(NCc2cc(O)ccc2O)ccc1O |
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| Storage condition | -20℃ |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 5-[(2,5-Dihydroxybenzyl)amino]-2-hydroxybenzoic acid |
| Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy- |
| hdba |
| compound 5 |
