Introduction：Basic information about CAS 118409-62-4|AG-126, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AG-126 |
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| CAS Number | 118409-62-4 | Molecular Weight | 215.165 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 381.9±42.0 °C at 760 mmHg |
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| Molecular Formula | C10H5N3O3 | Melting Point | 184 °C |
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| MSDS | / | Flash Point | 184.8±27.9 °C |
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Names
| Name | 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile |
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| Synonym | More Synonyms |
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AG-126 BiologicalActivity
| Description | AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2). |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| Target | ERK2 |
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| References | [1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 381.9±42.0 °C at 760 mmHg |
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| Melting Point | 184 °C |
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| Molecular Formula | C10H5N3O3 |
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| Molecular Weight | 215.165 |
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| Flash Point | 184.8±27.9 °C |
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| Exact Mass | 215.033096 |
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| PSA | 113.63000 |
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| LogP | 1.66 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.689 |
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| InChIKey | DUQADSPERJRQBW-UHFFFAOYSA-N |
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| SMILES | N#CC(C#N)=Cc1ccc([N+](=O)[O-])c(O)c1 |
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| Storage condition | −20°C |
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Safety Information
| Hazard Codes | T: Toxic; |
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| Risk Phrases | 23/24/25 |
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| Safety Phrases | 26-36-45 |
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| WGK Germany | 3 |
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Synonyms
| (3-hydroxy-4-nitrobenzylidene)propanedinitrile |
| Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]- |
| Tyrphostin AG 126 |
| Tyrphostin AG127 |
| AG-126 |
| (3-Hydroxy-4-nitrobenzylidene)malononitrile |
| AG 127 |
| AG126 |
