CAS 14439-61-3|4'-Chlorodiazepam

Introduction：Basic information about CAS 14439-61-3|4'-Chlorodiazepam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles39
7. Synonyms

Common Name	4'-Chlorodiazepam
CAS Number	14439-61-3	Molecular Weight	319.18500
Density	1.35g/cm3	Boiling Point	517.1ºC at 760mmHg
Molecular Formula	C₁₆H₁₂Cl₂N₂O	Melting Point	160-163ºC
MSDS	ChineseUSA	Flash Point	266.6ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	4'-Chlorodiazepam
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.35g/cm3
Boiling Point	517.1ºC at 760mmHg
Melting Point	160-163ºC
Molecular Formula	C₁₆H₁₂Cl₂N₂O
Molecular Weight	319.18500
Flash Point	266.6ºC
Exact Mass	318.03300
PSA	32.67000
LogP	3.30780
Vapour Pressure	8.43E-11mmHg at 25°C
Index of Refraction	1.647
InChIKey	PUMYFTJOWAJIKF-UHFFFAOYSA-N
SMILES	CN1C(=O)CN=C(c2ccc(Cl)cc2)c2cc(Cl)ccc21

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF0500000

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-

CAS REGISTRY NUMBER :: 14439-61-3

BEILSTEIN REFERENCE NO. :: 0685202

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-Cl2-N2-O

MOLECULAR WEIGHT :: 319.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22
RIDADR	UN 2811
RTECS	DF0500000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles39

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

J. Med. Chem. 49 , 5845-8, (2006)

Cultured rat astrocytes and C6 rat glioma were used as a differential screen for a variety of 1,2,3,4-tetrahydroisoquinoline (THI) derivatives. Compound 1 [1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydrois...

Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.

Life Sci. 92(6-7) , 345-51, (2013)

This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity.Gene expression analyse...

Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.

Biochem. Pharmacol. 97 , 99-110, (2015)

As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm...

Synonyms

Chlorodiazepam

4'-Chlorodiazepam

7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

Ro-5-4864

7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

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