CAS 1210-35-1|Dibenzosuberone

Introduction：Basic information about CAS 1210-35-1|Dibenzosuberone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles5
7. Synonyms

Common Name	Dibenzosuberone
CAS Number	1210-35-1	Molecular Weight	208.255
Density	1.2±0.1 g/cm3	Boiling Point	378.3±0.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₂O	Melting Point	32-34 °C(lit.)
MSDS	ChineseUSA	Flash Point	158.3±20.1 °C

Names

Name	Dibenzosuberone
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	378.3±0.0 °C at 760 mmHg
Melting Point	32-34 °C(lit.)
Molecular Formula	C₁₅H₁₂O
Molecular Weight	208.255
Flash Point	158.3±20.1 °C
Exact Mass	208.088821
PSA	17.07000
LogP	4.45
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.618
InChIKey	BMVWCPGVLSILMU-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2CCc2ccccc21
Water Solubility	insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP1149700

CHEMICAL NAME :: 5H-Dibenzo(a,d)cyclohepten-5-one, 10,11-dihydro-

CAS REGISTRY NUMBER :: 1210-35-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O

MOLECULAR WEIGHT :: 208.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,186,1992 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 uL/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Behavioral - coma

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,186,1992

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HP1149700
HS Code	29143900

Customs

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles5

The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.

Pharmeur. Sci. Notes 2005(1) , 15-20, (2005)

An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has be...

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

J. Med. Chem. 56(1) , 241-53, (2013)

p38α mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory diseases. Nevertheless, no inhibitor of p38α MAP kinase has been introduced to the market. This mi...

Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

J. Med. Chem. 55(12) , 5868-77, (2012)

Synthesis, biological testing, structure-activity relationships (SARs), and selectivity of novel disubstituted dibenzosuberone derivatives as p38 MAP kinase inhibitors are described. Hydrophilic moiet...

Synonyms

5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-one

5H-Dibenzo[a,d]cyclohepten-5-one, 10,11-dihydro-

10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-one

Dibenzosuberone

EINECS 214-912-3

L C676 BV&T&J

MFCD00003587

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