CAS 26473-47-2|Captopril EP Impurity C
| Common Name | Captopril EP Impurity C | ||
|---|---|---|---|
| CAS Number | 26473-47-2 | Molecular Weight | 120.170 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 232.5±23.0 °C at 760 mmHg |
| Molecular Formula | C4H8O2S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 94.4±22.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-methyl-3-sulfanylpropanoic acid |
|---|---|
| Synonym | More Synonyms |
Captopril EP Impurity C BiologicalActivity
| Description | Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL. [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 232.5±23.0 °C at 760 mmHg |
| Molecular Formula | C4H8O2S |
| Molecular Weight | 120.170 |
| Flash Point | 94.4±22.6 °C |
| Exact Mass | 120.024498 |
| PSA | 76.10000 |
| LogP | 0.78 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.491 |
| InChIKey | MHRDCHHESNJQIS-UHFFFAOYSA-N |
| SMILES | CC(CS)C(=O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles5
More Articles| The utilization of 3-mercapto-2-methylpropionate as sulphur source by a phototrophic bacterium. Bioorg. Med. Chem. 2(7) , 589-93, (1994) A bacterium (strain photoB) photoassimilated 3-mercapto-2-methylpropionate as sole source of sulphur with methacrylate accumulating in the medium. This was thought to be the product of a sulphur-lyase... | |
| Bacterial taxa that limit sulfur flux from the ocean. Science 314(5799) , 649-52, (2006) Flux of dimethylsulfide (DMS) from ocean surface waters is the predominant natural source of sulfur to the atmosphere and influences climate by aerosol formation. Marine bacterioplankton regulate sulf... | |
| Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate. J. Bacteriol. 179(22) , 6902-11, (1997) During growth on acetate, Methanosarcina barkeri expresses catabolic enzymes for other methanogenic substrates such as monomethylamine. The range of substrates used by cells grown on acetate was furth... |
Synonyms
| (2RS)-2-Methyl-3-sulphanylpropanoic acid 3-Mercaptoisobutyric acid |
| Captopril impurity C |
| EINECS 247-726-6 |
| Propanoic acid, 3-mercapto-2-methyl- |
| 3-sulfhydryl isobutyric acid |
| 3-mercapto-2-methylpropionic acid |
| 3-mercapto-2-methylpropanoic acid |
| 3-Mercaptoisobutyric acid |
| MFCD00671555 |
| UNII:V3E4016VAS |
| 3-Mercapto-2-methyl propanoic acid |
| 2-Methyl-3-sulfanylpropanoic acid |
| Captopril Impurity 3 |
