CAS 300-84-5|HYPOTAURINE
| Common Name | HYPOTAURINE | ||
|---|---|---|---|
| CAS Number | 300-84-5 | Molecular Weight | 109.147 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 354.9±44.0 °C at 760 mmHg |
| Molecular Formula | C2H7NO2S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 168.5±28.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | hypotaurine |
|---|---|
| Synonym | More Synonyms |
HYPOTAURINE BiologicalActivity
| Description | Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2]. |
| In Vivo | Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3]. |
| Animal Admin | Rats: A radiant heat source is focused on the middle part of the rat’s tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4–5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3]. |
| References | [1]. Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073(1):91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756 [2]. Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7(12):15200-14. [3]. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43(1):397-404. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 354.9±44.0 °C at 760 mmHg |
| Molecular Formula | C2H7NO2S |
| Molecular Weight | 109.147 |
| Flash Point | 168.5±28.4 °C |
| Exact Mass | 109.019745 |
| PSA | 82.53000 |
| LogP | -2.03 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.616 |
| InChIKey | VVIUBCNYACGLLV-UHFFFAOYSA-N |
| SMILES | NCCS(=O)O |
| Storage condition | Desiccate at RT |
| Water Solubility | H2O: 100 mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Ethanesulfinic acid, 2-amino- |
| 2-Aminoethanesulfinic acid |
| 2-Amino-aethansulfinsaeure |
| MFCD00038197 |
| aminoethylsulfinic acid |
| 2-amino-Ethanesulfinic acid |
| 2-aminoethanesulfinate |
| Cystaminesulfinic acid |
| 2-Aminoethylsulfinate |
| 2-Aminoethylsulfinic acid |
| Ethanesulfinic acid,2-amino |
| Hypotaurine |
| Cystaminesulfinate |
