CAS 543-15-7|6-amino-2-methylheptan-2-ol,hydrochloride
Introduction：Basic information about CAS 543-15-7|6-amino-2-methylheptan-2-ol,hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Heptaminol hydrochloride is a vasoconstrictor, used in the treatment of low blood pressure, particularly orthostatic hypotension.in vivo: In the rat, Heptaminol hydrochloride prevents orthostatic hypotension, and increases the noradrenaline plasma concentration. In bovine chromaffin cells maintained in primary cultures, Heptaminol hydrochloride is found to be a competitive inhibitor of noradrenaline uptake.[1]
Related Catalog
Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease
References
[1]. Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49(3):127-138.
Chemical & Physical Properties
Density
0.895g/cm3
Boiling Point
250.1ºC at 760mmHg
Melting Point
165-167 °C(lit.)
Molecular Formula
C8H20ClNO
Molecular Weight
181.70300
Flash Point
105.1ºC
Exact Mass
181.12300
PSA
46.25000
LogP
2.77710
InChIKey
JZNBMCOSOXIZJB-UHFFFAOYSA-N
SMILES
CC(N)CCCC(C)(C)O.Cl
Storage condition
2-8℃
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
MJ3240000
CHEMICAL NAME :
2-Heptanol, 6-amino-2-methyl-, hydrochloride
CAS REGISTRY NUMBER :
543-15-7
LAST UPDATED :
199012
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H19-N-O.Cl-H
MOLECULAR WEIGHT :
181.74
WISWESSER LINE NOTATION :
ZY1&3XQ1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
28 ug/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Kidney, Ureter, Bladder - urine volume increased Skin and Appendages - sweating
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,178,1951
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,515,1970
Safety Information
Hazard Codes
Xi
Risk Phrases
36/37/38
Safety Phrases
S22-S24/25
RIDADR
NONH for all modes of transport
WGK Germany
3
RTECS
MJ3240000
HS Code
2922199090
Customs
HS Code
2922199090
Summary
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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