Introduction：Basic information about CAS 305-33-9|Iproniazid (phosphate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Iproniazid (phosphate) |
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| CAS Number | 305-33-9 | Molecular Weight | 277.21400 |
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| Density | 1.084g/cm3 | Boiling Point | 265.9ºC at 760mmHg |
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| Molecular Formula | C9H16N3O5P | Melting Point | 181ºC |
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| MSDS | / | Flash Point | 114.6ºC |
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Names
| Name | iproniazid phosphate |
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| Synonym | More Synonyms |
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Iproniazid (phosphate) BiologicalActivity
| Description | Iproniazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| References | [1]. Robert A,et al. Drug discovery. Humana Press. pp. 143–154. [2]. Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387 |
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Chemical & Physical Properties
| Density | 1.084g/cm3 |
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| Boiling Point | 265.9ºC at 760mmHg |
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| Melting Point | 181ºC |
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| Molecular Formula | C9H16N3O5P |
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| Molecular Weight | 277.21400 |
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| Flash Point | 114.6ºC |
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| Exact Mass | 277.08300 |
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| PSA | 141.59000 |
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| LogP | 0.57760 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NS1950000
- CHEMICAL NAME :
- Isonicotinic acid, 2-isopropylhydrazide, phosphate
- CAS REGISTRY NUMBER :
- 305-33-9
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C9-H13-N3-O.H3-O4-P
- MOLECULAR WEIGHT :
- 277.25
- WISWESSER LINE NOTATION :
- T6NJ DVMMY1&1 &QPQQO
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 442 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - parasympatholytic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 10-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 640 mg/kg
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982
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Safety Information
| Hazard Codes | T: Toxic; |
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| Risk Phrases | 23/24/25 |
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| Safety Phrases | S24/25 |
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| RIDADR | UN 3249 |
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| RTECS | NS1950000 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933399090 |
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Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-pyridinecarboxylic acid |
| iproniaziddihydrogenphosphate |
| IPRONIAZID PHOSPHATE SALT |
| N'-Isopropylisonicotinohydrazide phosphate |
| 1-Isonicotinyl-2-isopropylhydrazine Phosphate |
| Iproniazidphosphat |
| phosphate (1:1) |
| ISONICOTINIC ACID 2-ISOPROPYLHYDRAZIDE PHOSPHATE |
| IPRONIAZID PHOSP |
| marsilidphosphate |
| 2-(1-methylethyl)hydrazide |
| EINECS 206-164-1 |
| iproniazidephosphate |
| Iproniazid (phosphate) |
