CAS 122965-43-9|METHYLENE BLUE
Introduction：Basic information about CAS 122965-43-9|METHYLENE BLUE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | METHYLENE BLUE | ||
|---|---|---|---|
| CAS Number | 122965-43-9 | Molecular Weight | 337.86800 |
| Density | 0.6600g/ml | Boiling Point | / |
| Molecular Formula | C16H20ClN3OS | Melting Point | 190ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | methylene blue |
|---|---|
| Synonym | More Synonyms |
METHYLENE BLUE BiologicalActivity
| Description | Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Immunology/Inflammation >>NO SynthaseSignaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Cytoskeleton >>Microtubule/TubulinSignaling Pathways >>GPCR/G Protein >>Guanylate Cyclase |
| In Vitro | Methylene blue (Basic Blue 9) hydrate (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA[3]. |
| In Vivo | Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition[1]. Methylene blue (Basic Blue 9) hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau[2]. Methylene blue (Basic Blue 9) hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior[3]. Methylene blue (Basic Blue 9) hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor[3]. Animal Model: Male NMRI mice[1] Dosage: 50 and 100 mg/kg Administration: Intraperitoneal injection; once, for 25 minutes Result: Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP). Animal Model: CaMKIIα-tTA transactivator mice[2] Dosage: 20 and 40 mg/kg Administration: Oral administration; daily, for 6 months Result: Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice. Animal Model: TBI-treated male BALB/c mice[3] Dosage: 2 mg/kg Administration: Intravenous injection; once, for 1 day Result: Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA. Animal Model: TBI-treated male BALB/c mice[3] Dosage: 2 mg/kg Administration: Intravenous injection; once, for 1 day Result: Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL-10 expression in microglia. |
| References | [1]. Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72. [2]. Hochgräfe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25. [3]. Fenn AM, et, al. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32(2):127-38. |
Chemical & Physical Properties
| Density | 0.6600g/ml |
|---|---|
| Melting Point | 190ºC |
| Molecular Formula | C16H20ClN3OS |
| Molecular Weight | 337.86800 |
| Exact Mass | 337.10200 |
| PSA | 56.61000 |
| Appearance of Characters | Fine Crystalline Powder | Green |
| Storage condition | room temp |
| Water Solubility | H2O: soluble4mg/4ml | Soluble in water, alcohol, acetic acid, glycerol and chloroform. Insoluble in ether. |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | 26-39-61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SO5600000 |
Articles2
More Articles| Functionalization of organically modified silica with gold nanoparticles in the presence of lignosulfonate. Int. J. Biol. Macromol. 85 , 74-81, (2016) It is shown that lignosulfonate (LS) can be used as an effective reducing agent for gold ions and simultaneously as a stabilizing agent for gold nanoparticles (AuNPs). When organically modified silica... | |
| On the efficiency of methylene blue versus persulfate catalysis of polyacrylamide gels, as investigated by capillary zone electrophoresis. Electrophoresis 14 , 997, (1993) The efficiency of a novel method of photopolymerization, based on photoinitiating the reaction with methylene blue (MB), in presence of a redox couple (sodium toluenesulfinate and diphenyliodonium chl... |
Synonyms
| Methylene Blue hydrate,high purity biological stain |
| MFCD00150006 |
| Methylene Blue,high purity |
| Methylene Blue |
| MethyleneblueHydrat |
| Methylene Blue hydrate |
| Methylthioninium chloride |
| EINECS 200-515-2 |
| Methylene Blue hydrate,Methylthionini chloridum |
