Introduction：Basic information about CAS 530-08-5|isoetarine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | isoetarine |
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| CAS Number | 530-08-5 | Molecular Weight | 239.31100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C13H21NO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol |
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| Synonym | More Synonyms |
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isoetarine BiologicalActivity
| Description | Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology |
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| In Vitro | Isoetharine (50 μM, 18 hours) can induce the production and release of [35S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells[1]. |
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| In Vivo | Isoetharine inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2]. |
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| References | [1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95. [2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812. |
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Chemical & Physical Properties
| Molecular Formula | C13H21NO3 |
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| Molecular Weight | 239.31100 |
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| Exact Mass | 239.15200 |
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| PSA | 72.72000 |
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| LogP | 2.29870 |
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| InChIKey | HUYWAWARQUIQLE-UHFFFAOYSA-N |
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| SMILES | CCC(NC(C)C)C(O)c1ccc(O)c(O)c1 |
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Safety Information
Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Isoetarina |
| isoetharine |
| Isoetarine |
| Bronkosol |
| Isoetarin |
| Etyprenalinum |
| 1-(3,4-dihydroxy-phenyl)-2-isopropylamino-butan-1-ol |
| Etyprenaline |
| Dilabron |
| Bronkometer |
| Isoetarinum |
