CAS 38234-21-8|(Des-Gly10,Pro-NHEt9)-LHRH acetate salt

Introduction：Basic information about CAS 38234-21-8|(Des-Gly10,Pro-NHEt9)-LHRH acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (Des-Gly10,Pro-NHEt9)-LHRH acetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(Des-Gly10,Pro-NHEt9)-LHRH acetate salt
CAS Number	38234-21-8	Molecular Weight	1153.292
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₅₅H₇₆N₁₆O₁₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	fertirelin
Synonym	More Synonyms

(Des-Gly10,Pro-NHEt9)-LHRH acetate salt BiologicalActivity

Description	Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides
In Vivo	Fertirelin, an analog of GnRH 2.5 to 10 times more potent than native GnRH , has become the treatment of choice for reversing follicular cysts[1]. Administration of high doses of Fertirelin is found to reduce superovulatory responses[2].
Animal Admin	Mice[2] Nulliparious female mice weighed 25-28 g (8-9 weeks) are used throughout the study. The mice are ddY strain and specific pathohen-free. As ovulation can be induced in mice at any time with administration of human chorionic gonadotrophin (hCG), 5.0 IU of hCG is injected subcutaneously into each mouse at 17:00, irrespective of the stage of the estrus cycle. This day is designated as Day 0. Nine groups are established according to the dose of Fertirelin ranging from 0.001 to 1.0 μg, and the administration are carried out at 22:00 on Day 0 and at 2:00, 6:00, 10:00 and 14:00 on Day 1[2].
References	[1]. Nakao T et al. Effect of fenprostalene 14 days after fertirelin treatment on intervals from treatment to conception in cows with follicular cysts diagnosed by milk progesterone test. J Vet Med Sci. 1993 Apr;55(2):207-10. [2]. Nariai K, et al. Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice. Exp Anim. 2005 Jan;54(1):97-9.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₅H₇₆N₁₆O₁₂
Molecular Weight	1153.292
Exact Mass	1152.582886
PSA	429.04000
LogP	-1.35
Index of Refraction	1.698
InChIKey	DGCPIBPDYFLAAX-YTAGXALCSA-N
SMILES	CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1
Storage condition	-15°C

Safety Information

Hazard Codes	T
Risk Phrases	60
Safety Phrases	53-22-36/37/39-45

Synonyms

UNII:Q041AO6T91

Fertireline [inn-french]

[DES-GLY10] LH-RH,ETHYL AMIDE

fertirelin

Fertirelin [inn:ban]

Fertirelina [inn-spanish]

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt

5-oxo-Pro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt

L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-

Fertireline

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NH-CH2-CH3

(DES-GLY10,PRO-NHET9)-LHRH

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide

Fertirelina

Fertirelin Acetate

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