CAS 552-66-9|Daidzin

Introduction：Basic information about CAS 552-66-9|Daidzin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Daidzin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles47
7. Synonyms

Common Name	Daidzin
CAS Number	552-66-9	Molecular Weight	416.378
Density	1.6±0.1 g/cm3	Boiling Point	727.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₀O₉	Melting Point	234-236°C
MSDS	ChineseUSA	Flash Point	259.8±26.4 °C

Names

Name	daidzein 7-O-β-D-glucoside
Synonym	More Synonyms

Daidzin BiologicalActivity

Description	Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Mitochondrial MetabolismNatural Products >>FlavonoidsResearch Areas >>Others
References	[1]. Xie CI, et al. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res. 1994 Dec;18(6):1443-7. [2]. Keung WM, et al. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998 Feb;47(4):499-506. [3]. Keung WM, et al. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1675-9.

Description

Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Mitochondrial MetabolismNatural Products >>FlavonoidsResearch Areas >>Others

References

[1]. Xie CI, et al. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res. 1994 Dec;18(6):1443-7.

[2]. Keung WM, et al. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998 Feb;47(4):499-506.

[3]. Keung WM, et al. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1675-9.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	727.6±60.0 °C at 760 mmHg
Melting Point	234-236°C
Molecular Formula	C₂₁H₂₀O₉
Molecular Weight	416.378
Flash Point	259.8±26.4 °C
Exact Mass	416.110718
PSA	149.82000
LogP	0.45
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.695
InChIKey	KYQZWONCHDNPDP-QNDFHXLGSA-N
SMILES	O=c1c(-c2ccc(O)cc2)coc2cc(OC3OC(CO)C(O)C(O)C3O)ccc12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3094000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hy droxy-

CAS REGISTRY NUMBER :: 552-66-9

BEILSTEIN REFERENCE NO. :: 0059741

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H20-O9

MOLECULAR WEIGHT :: 416.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3094000

Articles47

Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix.

J. Ethnopharmacol. 164 , 53-63, (2015)

Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchange...

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer.

Cancer Prev. Res. (Phila.) 8 , 1045-54, (2015)

Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted ...

Synonyms

daidzein 7-O-β-D-glucoside

Daidzein 7-O-glucoside

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-

4'-hydroxyisoflavone-7-O-glucoside

Daidzin

Daidzein-7-glucoside

3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

4',7-hydroxyisoflavone-7-glucoside

MFCD00017466

3-(4-Hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside

Daidzein-7-O-β-D-glucopyranoside

4',7-dihydroxyisoflavone-7-D-glucoside

7-O-B-D-GLUCOPYRANOSIDE

Diadzein 7-O-glucoside

Daidzoside

daidzein 7-O-beta-D-glucoside

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