CAS 598-78-7|2-Chloropropanoic acid

Introduction：Basic information about CAS 598-78-7|2-Chloropropanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles27
7. Synonyms

Common Name	2-Chloropropanoic acid
CAS Number	598-78-7	Molecular Weight	108.524
Density	1.3±0.1 g/cm3	Boiling Point	189.0±13.0 °C at 760 mmHg
Molecular Formula	C₃H₅ClO₂	Melting Point	-12--14 °C
MSDS	ChineseUSA	Flash Point	101.7±0.0 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	2-Chloropropionic acid
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	189.0±13.0 °C at 760 mmHg
Melting Point	-12--14 °C
Molecular Formula	C₃H₅ClO₂
Molecular Weight	108.524
Flash Point	101.7±0.0 °C
Exact Mass	107.997810
PSA	37.30000
LogP	0.30
Vapour Pressure	0.3±0.7 mmHg at 25°C
Index of Refraction	1.441
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	freely soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE8575000

CHEMICAL NAME :: Propionic acid, 2-chloro-

CAS REGISTRY NUMBER :: 598-78-7

BEILSTEIN REFERENCE NO. :: 1720259

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C3-H5-Cl-O2

MOLECULAR WEIGHT :: 108.53

WISWESSER LINE NOTATION :: QVYG1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 126 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,136(89),1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7182 mg/kg/42D-C

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus Skin and Appendages - hair Related to Chronic Data - changes in testicular weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355 *** REVIEWS *** ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive
Risk Phrases	R21/22;R35
Safety Phrases	S23-S26-S28-S36-S45-S36/37/39-S28A
RIDADR	UN 2511 8/PG 3
WGK Germany	1
RTECS	UE8575000
Packaging Group	III
Hazard Class	8
HS Code	29159080

Customs

HS Code	29159080

Articles27

Haloalkanoate dehalogenase II (DehE) of a Rhizobium sp.--molecular analysis of the gene and formation of carbon monoxide from trihaloacetate by the enzyme.

Eur. J. Biochem. 250(3) , 789-93, (1997)

A 3-kb EcoRI fragment of genomic DNA from a Rhizobium sp. cloned into pUC19 endowed Escherichia coli K-12 with the ability to grow, albeit slowly, with 2-chloropropionic acid as substrate. The constru...

Direct determination of the enantiomeric purity or enantiomeric composition of methylpropionates using a single capacitive microsensor.

Anal. Chem. 81(5) , 1969-75, (2009)

Capacitive enantioselective sensors have been demonstrated to provide antipodal signals upon dosage of, e.g., the enantiomers of methyl lactate or methyl-2-chloropropionate. In a next step, these sens...

Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.

Adv. Exp. Med. Biol. 500 , 23-31, (2001)

Synonyms

QVYG1

2-Chloropropionicacid

2-Chloropropanoic acid

2-chloro-propionicaci

EINECS 209-952-3

2-Chloropropionic ac

Propionic acid, α-chloro-

RARECHEM AL BO 1240

2-chloropropionic

2-chloro-propanoicaci

Propanoic acid, 2-chloro-

MFCD00004224

α-Monochloropropanoic acid

2-Chlorpropionsure

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