CAS 305-84-0|L-carnosine
Introduction：Basic information about CAS 305-84-0|L-carnosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-carnosine | ||
|---|---|---|---|
| CAS Number | 305-84-0 | Molecular Weight | 226.232 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 656.2±55.0 °C at 760 mmHg |
| Molecular Formula | C9H14N4O3 | Melting Point | 253 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 350.7±31.5 °C |
Names
| Name | carnosine |
|---|---|
| Synonym | More Synonyms |
L-carnosine BiologicalActivity
| Description | L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1]. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2]. |
| References | [1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74. [2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 656.2±55.0 °C at 760 mmHg |
| Melting Point | 253 °C (dec.)(lit.) |
| Molecular Formula | C9H14N4O3 |
| Molecular Weight | 226.232 |
| Flash Point | 350.7±31.5 °C |
| Exact Mass | 226.106583 |
| PSA | 121.10000 |
| LogP | -2.17 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.591 |
| InChIKey | CQOVPNPJLQNMDC-ZETCQYMHSA-N |
| SMILES | NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >14930 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9087 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 21 mg/kg
- SEX/DURATION :
- female 8-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1219,1974
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | MS3080000 |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles54
More Articles| Hydrogel-based ultra-moisturizing cream formulation for skin hydration and enhanced dermal drug delivery. Biol. Pharm. Bull. 37(10) , 1674-82, (2014) To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL,... | |
| Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods. Anal. Sci. 31 , 805-14, (2015) To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit... | |
| Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry. Electrophoresis 35(23) , 3321-30, (2014) There is high interest in the discovery of early diagnostic biomarkers of Alzheimer's disease, for which metabolomics exhibits a great potential. In this work, a metabolomic approach based on ultrafil... |
Synonyms
| (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid |
| N-b-Alanyl-L-histidine |
| EINECS 206-169-9 |
| L-Histidine, N-β-alanyl- |
| β-Alanyl-L-histidine |
| N-(b-Alanyl)-L-histidine |
| N-β-Alanyl-L-histidin |
| beta-Alanyl-L-histidine |
| ignotine |
| n-2-m |
| L-IGNOTINE |
| carnosine |
| L-Histidine, N-(3-amino-1-hydroxypropylidene)-, (E)- |
| karnozzn |
| Carnosin |
| L-Carnosine |
| L-Histidine, β-alanyl- |
| MFCD00005207 |
| N-β-Alanyl-L-histidine |
| (E)-N-(3-Amino-1-hydroxypropylidene)-L-histidine |
| Karnozin |
| H-β-Ala-His-OH |
