CAS 149759-96-6|FTase Inhibitor I
| Common Name | FTase Inhibitor I | ||
|---|---|---|---|
| CAS Number | 149759-96-6 | Molecular Weight | 470.69 |
| Density | 1.161g/cm3 | Boiling Point | 716.1ºC at 760mmHg |
| Molecular Formula | C22H38N4O3S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 386.9ºC |
Names
| Name | b 581 |
|---|---|
| Synonym | More Synonyms |
FTase Inhibitor I BiologicalActivity
| Description | Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Farnesyl Transferase |
| In Vitro | Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar[1]. |
| References | [1]. A D Cox, et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29;269(30):19203-6. |
Chemical & Physical Properties
| Density | 1.161g/cm3 |
|---|---|
| Boiling Point | 716.1ºC at 760mmHg |
| Molecular Formula | C22H38N4O3S2 |
| Molecular Weight | 470.69 |
| Flash Point | 386.9ºC |
| Exact Mass | 470.23900 |
| PSA | 180.58000 |
| LogP | 3.25410 |
| Appearance of Characters | solid | white |
| Vapour Pressure | 1.6E-21mmHg at 25°C |
| Index of Refraction | 1.566 |
| InChIKey | QISLMXIYRQCLIR-FUMNGEBKSA-N |
| SMILES | CSCCC(NC(=O)C(Cc1ccccc1)NCC(NCC(N)CS)C(C)C)C(=O)O |
| Storage condition | −20°C |
| Water Solubility | H2O: soluble |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles8
More Articles| [Anti tumor activity of farnesyl transferase inhibitor]. Gan To Kagaku Ryoho. 24(2) , 145-55, (1997) Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B... | |
| Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis. Oncogene 18(35) , 4930-9, (1999) IL-2 deprivation triggers apoptosis in the murine T cell line TS1alphabeta, a process that can be blocked by overexpression of Bcl-2. Here we show that Bcl-2 and Ras proteins interact in mitochondria ... | |
| Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J. Biol. Chem. 268(25) , 18415-8, (1993) The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, t... |
Synonyms
| (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid |
| B581 |
