Introduction：Basic information about CAS 70763-62-1|2-Deoxy-2-fluoro-L-fucose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Deoxy-2-fluoro-L-fucose |
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| CAS Number | 70763-62-1 | Molecular Weight | 166.14800 |
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| Density | 1.335g/cm3 | Boiling Point | 386.5ºC at 760 mmHg |
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| Molecular Formula | C6H11FO4 | Melting Point | / |
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| MSDS | / | Flash Point | 187.6ºC |
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Names
| Name | 2-Deoxy-2-fluoro-L-fucose |
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2-Deoxy-2-fluoro-L-fucose BiologicalActivity
| Description | 2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | 2-Deoxy-2-fluoro-L-fucose (2FF) (100-500 μM)) suppresses fucosylation in 4T1 cells[1]. 2-Deoxy-2-fluoro-L-fucose (100 μM; 4T1 cells) decreases phosphorylation of Smad 1/5 and Smad 2[1]. |
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| References | [1]. Herrera H, et al. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019;20(10):2528. Published 2019 May 23. |
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Chemical & Physical Properties
| Density | 1.335g/cm3 |
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| Boiling Point | 386.5ºC at 760 mmHg |
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| Molecular Formula | C6H11FO4 |
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| Molecular Weight | 166.14800 |
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| Flash Point | 187.6ºC |
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| Exact Mass | 166.06400 |
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| PSA | 69.92000 |
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| Index of Refraction | 1.469 |
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| InChIKey | SQTFKIKSQNCWGJ-KCDKBNATSA-N |
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| SMILES | CC(O)C(O)C(O)C(F)C=O |
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Safety Information
