CAS 4025-59-6|(3-beta,5-beta,6-beta)-5,6-Epoxycholestan-3-ol
Introduction：Basic information about CAS 4025-59-6|(3-beta,5-beta,6-beta)-5,6-Epoxycholestan-3-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. [1] [2] Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. [3] 5β,6β-epoxycholestanol has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue. [4] References: [1]. Pulfer, MK, and Murphy, RC Formation of bioactive oxygen sterols during ozonolysis of cholesterol present in lung surfactants. Journal of Biochemistry 279(25), 26331-26338 (2004). [2]. Aringer, L. and Eneroth, P. In vitro formation and metabolism of cholesterol and β-sitosterol 5,6-epoxides. J. Lipid Research. 15(4), 389-398 (1974).[3]. Lordan, S., O'Brien, NM, and Mackrill, JJ Calcium in 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide-induced apoptosis. J. Biochemistry. Moore. poison. 23(5), 324-332 (2009).[4]. Garcia-Cruset, S., Carpenter, KL, Guardiola, F. et al. Oxysterol profiles of normal human arteries, fatty streaks, and advanced lesions. free radicals. reservoir. 35(1), 31-41 (2001).
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes
Xn
Risk Phrases
20/21/22-48/20/21/22
Safety Phrases
7-36/37
RIDADR
NONH for all modes of transport
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Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant.
J. Biol. Chem. 279(25) , 26331-8, (2004)
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The cytotoxicity of the oxysterols 25-hydroxycholesterol, 7beta-hydroxycholesterol, cholesterol-5alpha,6alphaepoxide, cholesterol-5beta,6beta-epoxide, 19-hydroxycholesterol and 7-ketocholesterol was e...
