Introduction：Basic information about CAS 85547-56-4|Piperaquine phosphate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Piperaquine phosphate |
|---|
| CAS Number | 85547-56-4 | Molecular Weight | 633.506 |
|---|
| Density | / | Boiling Point | 721.1ºC at 760mmHg |
|---|
| Molecular Formula | C29H35Cl2N6O4P | Melting Point | / |
|---|
| MSDS | / | Flash Point | 389.9ºC |
|---|
Names
| Name | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate |
|---|
| Synonym | More Synonyms |
|---|
Piperaquine phosphate BiologicalActivity
| Description | Piperaquine is a bisquinoline antimalarial agent, often as a partner antimalarial for artemisinin drug-based combination therapy (ACT)[1][2]. |
|---|
| Related Catalog | Research Areas >>Infection |
|---|
| In Vivo | Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1]. Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1]. Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] Dosage: 0, 10, 30, 90 mg/kg Administration: A single i.p. administration Result: The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. Animal Model: Male Swiss mice (6 weeks old)[1] Dosage: 90 mg/kg (Pharmacokinetic Analysis) Administration: A single i.p. administration Result: t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
|---|
| References | [1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. [2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. |
|---|
Chemical & Physical Properties
| Boiling Point | 721.1ºC at 760mmHg |
|---|
| Molecular Formula | C29H35Cl2N6O4P |
|---|
| Molecular Weight | 633.506 |
|---|
| Flash Point | 389.9ºC |
|---|
| Exact Mass | 632.183472 |
|---|
| PSA | 126.31000 |
|---|
| LogP | 4.50130 |
|---|
| InChIKey | KATNPMSTHHZOTK-UHFFFAOYSA-N |
|---|
| SMILES | Clc1ccc2c(N3CCN(CCCN4CCN(c5ccnc6cc(Cl)ccc56)CC4)CC3)ccnc2c1.O=P(O)(O)O |
|---|
| Storage condition | -20℃ |
|---|
Safety Information
Customs
Synonyms
| 4,4'-(Propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline) phosphate (1:1) |
| Piperaquine phosphate |
| 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate (1:1) |
| Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-, phosphate (1:1) |
