CAS 1197958-12-5|AP26113

Introduction：Basic information about CAS 1197958-12-5|AP26113, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. AP26113 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	AP26113
CAS Number	1197958-12-5	Molecular Weight	529.014
Density	1.3±0.1 g/cm3	Boiling Point	737.6±70.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄ClN₆O₂P	Melting Point	/
MSDS	/	Flash Point	399.9±35.7 °C

Names

Name	5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
Synonym	More Synonyms

AP26113 BiologicalActivity

Description	ALK-IN-1 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ALKResearch Areas >>Cancer
References	[1]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1 [2]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1

Description

ALK-IN-1 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ALKResearch Areas >>Cancer

References

[1]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1

[2]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	737.6±70.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄ClN₆O₂P
Molecular Weight	529.014
Flash Point	399.9±35.7 °C
Exact Mass	528.216919
PSA	95.66000
LogP	1.10
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.626
Storage condition	-20°C

Synonyms

2,4-Pyrimidinediamine, 5-chloro-N-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N-[2-(dimethylphosphinyl)phenyl]-

5-Chloro-N-{4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl}-N-[2-(dimethylphosphoryl)phenyl]-2,4-pyrimidinediamine

AP26113

Brigatinib

ALK-IN-1

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