Introduction：Basic information about CAS 951393-55-8|Trandolaprilat Monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trandolaprilat Monohydrate |
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| CAS Number | 951393-55-8 | Molecular Weight | 420.49900 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H32N2O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Trandolaprilat Monohydrate |
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| Synonym | More Synonyms |
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Trandolaprilat Monohydrate BiologicalActivity
| Description | Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE) |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517. [2]. Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72. |
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Chemical & Physical Properties
| Molecular Formula | C22H32N2O6 |
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| Molecular Weight | 420.49900 |
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| Exact Mass | 420.22600 |
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| PSA | 116.17000 |
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| LogP | 2.55930 |
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| InChIKey | RCVUTQVXMHPLKS-CNTNIUBLSA-N |
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| SMILES | CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1C(C(=O)O)CC2CCCCC21.O |
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Synonyms
| (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid, hydrate |
| Trandolaprilate Monohydrate |
