CAS 212142-18-2|Vatalanib succinate
Introduction：Basic information about CAS 212142-18-2|Vatalanib succinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Vatalanib succinate | ||
|---|---|---|---|
| CAS Number | 212142-18-2 | Molecular Weight | 464.90 |
| Density | / | Boiling Point | 587.8ºC at 760 mmHg |
| Molecular Formula | C24H21ClN4O4 | Melting Point | 195ºC |
| MSDS | / | Flash Point | 309.3ºC |
Names
| Name | butanedioic acid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine |
|---|---|
| Synonym | More Synonyms |
Vatalanib succinate BiologicalActivity
| Description | Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
| Target | KDR:37 nM (IC50) Flt-1:77 nM (IC50) Flt-4:730 nM (IC50) |
| References | [1]. J M Wood, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60(8):2178-89. |
Chemical & Physical Properties
| Boiling Point | 587.8ºC at 760 mmHg |
|---|---|
| Melting Point | 195ºC |
| Molecular Formula | C24H21ClN4O4 |
| Molecular Weight | 464.90 |
| Flash Point | 309.3ºC |
| Exact Mass | 464.125122 |
| PSA | 125.30000 |
| LogP | 5.02140 |
| Vapour Pressure | 8.48E-14mmHg at 25°C |
| InChIKey | LLDWLPRYLVPDTG-UHFFFAOYSA-N |
| SMILES | Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1.O=C(O)CCC(=O)O |
Synonyms
| N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1) |
| PTK787 |
| 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate |
| Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1) |
| 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1) |
| N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate |
| N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1) |
| (4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate |
| N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1) |
| (4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate |
| Vatalanib |
| T66 CNNJ BMR DG& E1- DT6NJ &&Succinate |
| Vatalanib succinate |
| PTK/ZK |
