Introduction：Basic information about CAS 2196-14-7|4',7-Dihydroxyflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4',7-Dihydroxyflavone |
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| CAS Number | 2196-14-7 | Molecular Weight | 254.238 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 512.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C15H10O4 | Melting Point | 324-325ºC |
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| MSDS | / | Flash Point | 201.2±23.6 °C |
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Names
| Name | 4',7-dihydroxyflavone |
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| Synonym | More Synonyms |
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4',7-Dihydroxyflavone BiologicalActivity
| Description | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>CCRSignaling Pathways >>Immunology/Inflammation >>CCRResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2] |
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| References | [1]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458. [2]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 512.8±50.0 °C at 760 mmHg |
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| Melting Point | 324-325ºC |
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| Molecular Formula | C15H10O4 |
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| Molecular Weight | 254.238 |
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| Flash Point | 201.2±23.6 °C |
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| Exact Mass | 254.057907 |
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| PSA | 70.67000 |
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| LogP | 2.54 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.699 |
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| InChIKey | LCAWNFIFMLXZPQ-UHFFFAOYSA-N |
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| SMILES | O=c1cc(-c2ccc(O)cc2)oc2cc(O)ccc12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LK8329000
- CHEMICAL NAME :
- Flavone, 4',7-dihydroxy-
- CAS REGISTRY NUMBER :
- 2196-14-7
- BEILSTEIN REFERENCE NO. :
- 0224356
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C15-H10-O4
- MOLECULAR WEIGHT :
- 254.25
- WISWESSER LINE NOTATION :
- T66 BO EVJ CR DQ& IQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914501900 |
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Customs
| HS Code | 2914501900 |
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| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 7,4'-Dihydroxyflavanone |
| 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)- |
| 7,4'-Dihydroxyflavone |
| FLAVONE,4',7-DIHYDROXY |
| 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one |
| 4',7-Dihydroxyflavone |
