CAS 51-67-2|Tyramine
Introduction：Basic information about CAS 51-67-2|Tyramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyramine | ||
|---|---|---|---|
| CAS Number | 51-67-2 | Molecular Weight | 137.179 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 275.1±23.0 °C at 760 mmHg |
| Molecular Formula | C8H11NO | Melting Point | 160-162 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 141.3±13.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | tyramine |
|---|---|
| Synonym | More Synonyms |
Tyramine BiologicalActivity
| Description | Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals[1]. Tyramine potentiates the postsynaptic inhibitory effects of norepinephrine on the firing of cortical neurones in the rat[2]. Although tyramine exists in three isomerie forms, the orthoisomer and metaisomers are present in very low concentrations and it is the paraisomer that is implied when reference is made to tyramine. The tyramines are generally present in nanogram/gram concentrations in brain tissue, but they have a very rapid turnover. The CNS role of tyramine is unclear, it has been suggested that it is involved in the modulation of dopamine synthesis and may also regulate norepinephrine turnover[3]. |
| References | [1]. Harrison WM, et al. The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry. 1984 Jul;41(7):681-5. [2]. BURN JH, et al. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314-36. [3]. Juorio AV, et al. A possible role for tyramines in brain function and some mental disorders. Gen Pharmacol. 1982;13(3):181-3. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 275.1±23.0 °C at 760 mmHg |
| Melting Point | 160-162 °C(lit.) |
| Molecular Formula | C8H11NO |
| Molecular Weight | 137.179 |
| Flash Point | 141.3±13.3 °C |
| Exact Mass | 137.084061 |
| PSA | 46.25000 |
| LogP | 1.38 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.600 |
| InChIKey | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
| SMILES | NCCc1ccc(O)cc1 |
| Storage condition | Refrigerator, Under Inert Atmosphere |
| Stability | Stable. Incompatible with strong acids, strong oxidizing agents. |
| Water Solubility | 1g/95mL (15 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 229 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - sympathomimetic
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracervical
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 137 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,19,1990
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 137 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,19,1990
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | SJ5950000 |
| HS Code | 2922299090 |
Customs
| HS Code | 2922299090 |
|---|---|
| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Phenol, 4-(ethylamino)- |
| Uteramine |
| Tyramin |
| MFCD00008193 |
| 4-Ethylaminophenol |
| Tocosine |
| 4-(2-aminoethyl)phenol |
| 4-(2-aminoethyl)-pheno |
| p-Hydroxyphenylethylamine |
| Tyrosamine |
| Systogene |
| 4-Hydroxyphenethylamine |
| p-Tyramine |
| 4-(Ethylamino)phenol |
| 4-(Ethylamino)benzolol |
| 2-(4-Hydroxyphenyl)ethylamine |
| EINECS 200-115-8 |
| 4-hydroxy-phenethylamine |
