Introduction：Basic information about CAS 2033-24-1|Meldrumic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,2-Dimethyl-1,3-dioxane-4,6-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
356.7±35.0 °C at 760 mmHg
Melting Point
92-96 °C(lit.)
Molecular Formula
C6H8O4
Molecular Weight
144.13
Flash Point
195.1±24.4 °C
Exact Mass
144.042252
PSA
52.60000
LogP
-1.40
Vapour Pressure
0.0±0.8 mmHg at 25°C
Index of Refraction
1.434
InChIKey
GXHFUVWIGNLZSC-UHFFFAOYSA-N
SMILES
CC1(C)OC(=O)CC(=O)O1
Storage condition
0-6°C
Water Solubility
2.5 g/100 mL (20 ºC)
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
JH0800000
CHEMICAL NAME :
m-Dioxane-4,6-dione, 2,2-dimethyl-
CAS REGISTRY NUMBER :
2033-24-1
BEILSTEIN REFERENCE NO. :
0117310
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H8-O4
MOLECULAR WEIGHT :
144.14
WISWESSER LINE NOTATION :
T6OV DVOTJ F1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04102
R36/37/38:Irritating to eyes, respiratory system and skin . R45:May cause cancer.
Safety Phrases
S37/39-S24/25
RIDADR
NONH for all modes of transport
WGK Germany
3
RTECS
JH0800000
HS Code
2934999090
Customs
HS Code
2934999090
Summary
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles33
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Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents.
Bioorg. Med. Chem. 18 , 5626-33, (2010)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical para...
One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.
Mol. Divers. 13(4) , 399-419, (2009)
A general review (138 references) focused on the recent advances in the application of Meldrum's acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-lik...
A new domino autocatalytic reaction leading to polyfunctionalized spiro[5.5]undecanes and dispiro[4.2.5.2]pentadecanes.
Org. Biomol. Chem. 7(10) , 2195-201, (2009)
A new domino autocatalytic reaction of imines with Meldrum's acid was described. In this reaction, a series of polycyclic spiro[5.5]undecane-1,5,9-trione and dispiro[4.2.5.2]pentadecane-9,13-dione der...
