CAS 1119-62-6|3,3'-Disulfanediyldipropanoic acid
| Common Name | 3,3'-Disulfanediyldipropanoic acid | ||
|---|---|---|---|
| CAS Number | 1119-62-6 | Molecular Weight | 210.271 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 431.1±30.0 °C at 760 mmHg |
| Molecular Formula | C6H10O4S2 | Melting Point | 155-158 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 214.5±24.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3,3′-Dithiodipropionic acid |
|---|---|
| Synonym | More Synonyms |
3,3'-Disulfanediyldipropanoic acid BiologicalActivity
| Description | Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| In Vitro | CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1]. CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1]. CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1]. |
| References | [1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 431.1±30.0 °C at 760 mmHg |
| Melting Point | 155-158 °C(lit.) |
| Molecular Formula | C6H10O4S2 |
| Molecular Weight | 210.271 |
| Flash Point | 214.5±24.6 °C |
| Exact Mass | 210.002045 |
| PSA | 125.20000 |
| LogP | 1.38 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.592 |
| InChIKey | YCLSOMLVSHPPFV-UHFFFAOYSA-N |
| SMILES | O=C(O)CCSSCCC(=O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | C:Corrosive; |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36 |
| RIDADR | 1759 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles7
More Articles| The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment. Altern. Lab. Anim. 43 , 101-27, (2015) The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum... | |
| Multifunctional disulfide-based cationic dextran conjugates for intravenous gene delivery targeting ovarian cancer cells. Mol. Pharm. 11(7) , 2250-61, (2014) A folate-decorated, disulfide-based cationic dextran conjugate having dextran as the main chain and disulfide-linked 1,4-bis(3-aminopropyl)piperazine (BAP) residues as the grafts was designed and succ... | |
| Electrochemical behavior of dopamine at a 3,3'-dithiodipropionic acid self-assembled monolayers. Talanta 72(2) , 427-33, (2007) Monolayers of 3,3'-dithiodipropionic acid (DTDPA) were prepared on a polycrystalline gold electrode through a self-assembly procedure to produce a gold 3,3'-dithiodipropionic acid self-assembled monol... |
Synonyms
| MFCD00002780 |
| 3-(2-carboxyethyldisulfanyl)propanoic acid |
| Propanoic acid, 3,3'-dithiobis- |
| 3,3'-Dithiodipropionic acid |
| 3,3'-Disulfanediyldipropanoic acid |
| EINECS 214-284-0 |
| 3,3-Dithiodipropionic Acid |
| 3,3‘-Dithiodipropionic acid |
