CAS 1477-68-5|3-Methoxytyramine hydrochloride
Introduction：Basic information about CAS 1477-68-5|3-Methoxytyramine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-Methoxytyramine hydrochloride | ||
|---|---|---|---|
| CAS Number | 1477-68-5 | Molecular Weight | 203.666 |
| Density | / | Boiling Point | 306.8ºC at 760 mmHg |
| Molecular Formula | C9H14ClNO2 | Melting Point | 213 - 215ºC |
| MSDS | ChineseUSA | Flash Point | 139.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-O-Methyldopamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
3-Methoxytyramine hydrochloride BiologicalActivity
| Description | 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | TAAR1[1] |
| In Vitro | The intensity of the fluorescence developed is in a linear relation to the amount of 3-Methoxytyramine hydrochloride presented in the sample up to at least 1 μg. When a high concentration of dopamine is present in the reaction mixture, there is some reduction in the fluorescence derived from 3-Methoxytyramine hydrochloride[1]. |
| In Vivo | The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity however, is mostly presented as a set of disorganized abnormal movements that includes tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 µg, at 9 µg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 µg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 µg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs[1]. |
| Cell Assay | The rats are killed by cervical dislocation and the brains are removed and placed on an ice-cooled glass plate. The corpora striata are dissected out and homogenized immediately or stored at -17°C until analyzed. For the estimation of 3-Methoxytyramine hydrochloride 1 mL of the neutralized perchloric acid solution is placed in a glass test tube. One millilitre of a solution of potassium ferricyanide (20 μg/mL) in concentrated ammonium hydroxide is added. After 2 min 0 to 1 mL of a solution of cysteine (1 mg/mL) is added and mixed. The fluorescence of the resulting solution is measured in a spectrophotofluorometer fitted with an interference filter in the fluorescence light path. A blank determination is made by reversing the order of the addition of the ferricyanide-ammonia solution and the solution of cysteine. Authentic 3-Methoxytyramine hydrochloride is also added to a portion of the neutralized eluate and the fluorescence developed to check for quenching[1]. |
| Animal Admin | To assess effects of 3-Methoxytyramine hydrochloride (3-MT) in normal and TAAR1-KO mice, the animals are placed in the locomotor activity chamber and 30 min later various doses of 3-Methoxytyramine hydrochloride are administered i.c.v.. To perform i.c.v. administration in this paradigm, habituated mice are removed from the experimental chamber, briefly restrained, i.c.v. injection cannula is placed into the previously implanted (one week before) guide cannula and infusion of 3-Methoxytyramine hydrochloride or vehicle is performed for 4 minutes when animal is freely moving in a home cage. After infusion, animals are put back into experimental chamber and behavior is monitored for 90 min after administration[1]. |
| References | [1]. Sotnikova TD, et al. The dopamine metabolite 3-methoxytyramine is a neuromodulator. PLoS One. 2010 Oct 18;5(10):e13452. [2]. Guldberg HC, et al. Some observations on the estimation of 3-methoxytyramine in brain tissue. Br J Pharmacol. 1971 Aug;42(4):505-11. |
Chemical & Physical Properties
| Boiling Point | 306.8ºC at 760 mmHg |
|---|---|
| Melting Point | 213 - 215ºC |
| Molecular Formula | C9H14ClNO2 |
| Molecular Weight | 203.666 |
| Flash Point | 139.3ºC |
| Exact Mass | 203.071304 |
| PSA | 55.48000 |
| LogP | 2.40430 |
| Vapour Pressure | 0.000418mmHg at 25°C |
| InChIKey | AWRIOTVUTPLWLF-UHFFFAOYSA-N |
| SMILES | COc1cc(CCN)ccc1O.Cl |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | F+ |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles32
More Articles| Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain. Biosci. Biotechnol. Biochem. 79 , 1542-7, (2015) In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose se... | |
| Facile synthesis of Fe₃O₄@polyethyleneimine modified with 4-formylphenylboronic acid for the highly selective extraction of major catecholamines from human urine. J. Sep. Sci. 38 , 2857-64, (2015) The levels of catecholamines, especially dopamine, epinephrine and norepinephrine in urine and plasma have been used to assist the diagnosis and treatment of psychosis. Due to their low endogenous con... | |
| Simultaneous analysis of multiple neurotransmitters by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry J. Chromatogr. A. 1395 , 79-87, (2015) • A novel HILIC-MS/MS method for neurotransmitters, precursors and metabolites analysis. • Different HILIC stationary phases were evaluated. • Zwitterionic stationary phases were the most suitable for... |
Synonyms
| 3-O-Methyldopamine hydrochloride |
| Homovanillylamine hydrochloride |
| 4-(2-Aminoethyl)-2-methoxyphenol hydrochloride |
| Phenol, 4-(2-aminoethyl)-2-methoxy-, hydrochloride (1:1) |
| 4-(2-aminoethyl)-2-methoxyphenol,hydrochloride |
| MFCD00012902 |
| EINECS 216-035-1 |
| 4-(2-Aminoethyl)-2-methoxyphenol hydrochloride (1:1) |
| Methoxytyramine |
| 3-Methoxytyramine hydrochloride |
