CAS 5169-78-8|tipepidine

Introduction：Basic information about CAS 5169-78-8|tipepidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. tipepidine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	tipepidine
CAS Number	5169-78-8	Molecular Weight	275.43200
Density	1.1947 (rough estimate)	Boiling Point	bp4-5 178-184°
Molecular Formula	C₁₅H₁₇NS₂	Melting Point	64-65°
MSDS	/	Flash Point	/

Names

Name	3-(dithiophen-2-ylmethylidene)-1-methylpiperidine
Synonym	More Synonyms

tipepidine BiologicalActivity

Description	Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
Target	IC50: 7.0 μM (dopamine D2 receptor)[1]
In Vivo	Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2]. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2] Dosage: 10, 20 and 40 mg/kg. Administration: I.p.; 0.5, 5, 23 hours. Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
References	[1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.

Chemical & Physical Properties

Density	1.1947 (rough estimate)
Boiling Point	bp4-5 178-184°
Melting Point	64-65°
Molecular Formula	C₁₅H₁₇NS₂
Molecular Weight	275.43200
Exact Mass	275.08000
PSA	59.72000
LogP	4.27500
Index of Refraction	1.5300 (estimate)
InChIKey	JWIXXNLOKOAAQT-UHFFFAOYSA-N
SMILES	CN1CCCC(=C(c2cccs2)c2cccs2)C1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7870000

CHEMICAL NAME :: Piperidine, 3-(di-2-thienylmethylene)-1-methyl-

CAS REGISTRY NUMBER :: 5169-78-8

BEILSTEIN REFERENCE NO. :: 0212554

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H17-N-S2

MOLECULAR WEIGHT :: 275.45

WISWESSER LINE NOTATION :: T6N CYTJ A1 CUY- BT5SJ&- BT5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 867 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 294 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,1482,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 308 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959

Safety Information

HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine

Bitiodin

Asverin

(1-Methyl-3-piperidylidene)di(2-thienyl)methane

Tipepidine [INN:DCF]

Tipepidine

3-(Di-[2]thienyl-methylen)-1-methyl-piperidin

Tipepidina [INN-Spanish]

Tipedine

Tipepidinum [INN-Latin]

(1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat

CR/662

AT 327

3-(di-[2]thienyl-methylene)-1-methyl-piperidine

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