Introduction：Basic information about CAS 808-48-0|Desoxycorticosterone pivalate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desoxycorticosterone pivalate |
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| CAS Number | 808-48-0 | Molecular Weight | 414.57800 |
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| Density | 1.111 g/cm3 | Boiling Point | 529.012ºC at 760 mmHg |
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| Molecular Formula | C26H38O4 | Melting Point | 198-204ºC |
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| MSDS | / | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 11-deoxycorticosterone pivalate |
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| Synonym | More Synonyms |
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Desoxycorticosterone pivalate BiologicalActivity
| Description | Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism[1][2]. |
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| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Others |
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| In Vivo | A starting dosage of 1.5 mg/kg Desoxycorticosterone pivalate (DOCP) is effective in controlling clinical signs and serum electrolyte concentrations in the majority of dogs with PH. An additional dose reduction often is needed to maintain an injection interval of 28-30 days. Young and growing animals seem to need higher dosages[1]. |
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| References | [1]. Sieber-Ruckstuhl NS, et al. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. J Vet Intern Med. 2019 May;33(3):1266-1271. [2]. Masticatory Muscle Myositis: Pathogenesis, Diagnosis, and Treatment. |
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Chemical & Physical Properties
| Density | 1.111 g/cm3 |
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| Boiling Point | 529.012ºC at 760 mmHg |
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| Melting Point | 198-204ºC |
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| Molecular Formula | C26H38O4 |
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| Molecular Weight | 414.57800 |
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| Exact Mass | 414.27700 |
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| PSA | 60.44000 |
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| LogP | 5.29290 |
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| Index of Refraction | 1.534 |
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| InChIKey | VVOIQBFMTVCINR-WWMZEODYSA-N |
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| SMILES | CC(C)(C)C(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU5021400
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-
- CAS REGISTRY NUMBER :
- 808-48-0
- BEILSTEIN REFERENCE NO. :
- 3174879
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C26-H38-O4
- MOLECULAR WEIGHT :
- 414.64
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 119 mg/kg/24W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in thyroid weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940- Volume(issue)/page/year: 54,1954,1993
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 + H312 + H332 |
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| Precautionary Statements | P261-P280-P301 + P312 + P330 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 21-pivaloyloxy-pregn-4-ene-3,20-dione |
| Desoxycorticosterone pivalate |
| neodin-depositum |
| MFCD00199992 |
| 21-Pivaloyloxy-pregn-4-en-3,20-dion |
| Percorten pivalate |
| deoxycorticosterone pivalate |
| percortenm |
| Desoxycortisone pivalate |
| DOC PIVALATE |
| docp |
| cortexonem |
| deoxycortonepivalate |
| desoxycortone pivalate |
| EINECS 212-366-0 |
