CAS 143443-90-7|Ifetroban

Introduction：Basic information about CAS 143443-90-7|Ifetroban, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ifetroban BiologicalActivity
3. Chemical & Physical Properties

Common Name	Ifetroban
CAS Number	143443-90-7	Molecular Weight	440.53200
Density	1.206g/cm3	Boiling Point	663.6ºC at 760mmHg
Molecular Formula	C₂₅H₃₂N₂O₅	Melting Point	/
MSDS	/	Flash Point	355.1ºC

Names

Name	Ifetroban

Ifetroban BiologicalActivity

Description	Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Prostaglandin Receptor
Target	Thromboxane A2 receptor[1]
In Vitro	Ifetroban is a long-acting thromboxane/prostaglandin endoperoxide receptor antagonist, with antiplatelet activity[1].
In Vivo	Ifetroban (20, 40 mg/kg/day, i.p.) shows no effect on the blood pressure in stroke-prone spontaneously hypertensive rats[1]. Ifetroban (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[2].
References	[1]. Johnson RA, et al. Effect of ifetroban, a thromboxane A2 receptor antagonist, in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1996 Feb;18(2):171-88. [2]. Schumacher WA, et al. Antiplatelet activity of the long-acting thromboxane receptor antagonist BMS 180,291 in monkeys. Prostaglandins. 1992 Nov;44(5):389-97.

Chemical & Physical Properties

Density	1.206g/cm3
Boiling Point	663.6ºC at 760mmHg
Molecular Formula	C₂₅H₃₂N₂O₅
Molecular Weight	440.53200
Flash Point	355.1ºC
Exact Mass	440.23100
PSA	101.66000
LogP	4.50640
Index of Refraction	1.566
InChIKey	BBPRUNPUJIUXSE-DXKRWKNPSA-N
SMILES	CCCCCNC(=O)c1coc(C2C3CCC(O3)C2Cc2ccccc2CCC(=O)O)n1

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